Evidence map›Paper›PMID 25009725›Full record

ArticleFacts, views & vision in ObGyn2014

The (t)WE lab Simplified IVF Procedure: First Births after freezing/thawing.

W Ombelet, J Van Blerkom, E Klerkx, M Janssen, N Dhont, G Mestdagh, G Nargund, R Campo

Abstract readCase Reports
In one paragraph

Article in Facts, views & vision in ObGyn, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

W OmbeletGenk Institute for Fertility Technology, Department of Obstetrics and Gynaecology, ZOL, Campus St Jan, Genk, Belgium. ; Faculty of Medicine and Life Sciences, Hasselt University, Agoralaan, 3590 Diepenbeek, Belgium.
J Van BlerkomColorado Reproductive Endocrinology, Rose Medical Center, Denver, Colorado.
E KlerkxGenk Institute for Fertility Technology, Department of Obstetrics and Gynaecology, ZOL, Campus St Jan, Genk, Belgium.
M JanssenGenk Institute for Fertility Technology, Department of Obstetrics and Gynaecology, ZOL, Campus St Jan, Genk, Belgium.
N DhontGenk Institute for Fertility Technology, Department of Obstetrics and Gynaecology, ZOL, Campus St Jan, Genk, Belgium.
G MestdaghGenk Institute for Fertility Technology, Department of Obstetrics and Gynaecology, ZOL, Campus St Jan, Genk, Belgium.
G NargundFaculty of Medicine and Life Sciences, Hasselt University, Agoralaan, 3590 Diepenbeek, Belgium.
R CampoGenk Institute for Fertility Technology, Department of Obstetrics and Gynaecology, ZOL, Campus St Jan, Genk, Belgium.
Hasselt University · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInfertility care is one of the most neglected health care issues in developing countries (DC), affecting more than 50 million couples. The social stigma of childlessness still leads to isolation and abandonment. Bilateral tubal occlusion due to sexually transmitted diseases and pregnancy-related infections is the most common cause of infertility in DC. Consequently most cases of infertility are only treatable by using assisted reproductive technologies which are either unavailable or too costly. Lowering the laboratory costs associated with IVF is a crucial step to make IVF affordable for a larger part of the world population. We recently developed and described a new simplified method of IVF culturing, called the (t)WE lab method. Our initial results in fresh IVF cycles showed that IVF methodology can be significantly simplified and result in successful outcomes at levels that compare favourably to those obtained in high resource programs. CASE-REPORTS: We report three pregnancies and four live births as a result of transferring five cryo/thawing embryos which were developed after using the simplified (t)WE lab system. The two singleton babies delivered vaginally, for the twin pregnancy a caesarean section was performed. All babies were healthy, the perinatal outcome was uneventful in all cases.

conclusionWe provide proof-of-principle evidence that transferring cryopreserved/thawed embryos obtained with our (t)WE lab simplified culture system can lead to successful pregnancies and healthy live births.

Indexed as

Accessible IVFassisted reproductioncryopreservationdeveloping countriesinfertility carelow-cost IVFsimplified IVFslow freezingthe walking egg project

Identifiers

PMID25009725
PMCPMC4086002
OpenAlexW1954501098

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.