Evidence map›Paper›PMID 25009661›Full record

ArticleOncology letters2014

Molecular analysis of pancreatic acinar cell cystadenomas: Evidence of a non-neoplastic nature.

Frank Bergmann, Sebastian Aulmann, Thilo Welsch, Esther Herpel, Jens Werner, Peter Schirmacher, Hendrik Bläker

Open access · diamondAbstract read
In one paragraph

Article in Oncology letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Symptomatic acinar cell cystadenoma of the pancreas.Journal of surgical case reports · 2023
    Article
  3. [Rare pancreatic tumors].Der Pathologe · 2021
    Review
  4. Pancreatic Acinar Cell Cystadenoma Mimicking Pancreatic Serous Cystadenoma.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2021
    Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Frank BergmannInstitute of Pathology, University of Heidelberg, Heidelberg D-69120, Germany.
Sebastian AulmannInstitute of Pathology, University of Heidelberg, Heidelberg D-69120, Germany.
Thilo WelschDepartment of General Surgery, University of Heidelberg, Heidelberg D-69120, Germany ; Institute of Pathology, Charité Berlin, Campus Mitte, Berlin D-10117, Germany.
Esther HerpelInstitute of Pathology, University of Heidelberg, Heidelberg D-69120, Germany.
Jens WernerDepartment of General Surgery, University of Heidelberg, Heidelberg D-69120, Germany.
Peter SchirmacherInstitute of Pathology, University of Heidelberg, Heidelberg D-69120, Germany.
Hendrik BläkerInstitute of Pathology, University of Heidelberg, Heidelberg D-69120, Germany ; Department of Surgery, University of Dresden, Dresden D-01307, Germany.
Heidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The biology of pancreatic acinar cell cystadenomas has not been clearly defined. However, a non-neoplastic process, caused by a cell differentiation failure leading to a cystic transformation, has been discussed, as well as a benign neoplastic lesion. Pancreatic acinar cell cystadenomas usually consist of thin-walled unilocular or multilocular cysts, and mural nodules have been described in two cases of a recent series. In one of these nodules, chromosomal imbalances were detected, which provided preliminary evidence for a neoplastic process. The aim of the current study was to further characterize the lesions by molecular analyses. In four cases without mural nodules, the clonality was assessed by performing mutational analyses within the highly variable displacement-loop region of the mitochondrial DNA. As a result, no closer correlation was identified between different foci within the tumors than between the tumors and adjacent normal pancreatic acinar tissue, indicating polyclonality of these lesions. Further molecular analyses revealed no mutations of the

Indexed as

clonalitycystic lesionmolecularpancreatic tumor

Identifiers

PMID25009661
PMCPMC4081433
OpenAlexW2050999344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.