ArticleFrontiers in endocrinology2014
Testosterone increases circulating dehydroepiandrosterone sulfate levels in the male rhesus macaque.
Article in Frontiers in endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Dehydroepiandrosterone (DHEA) as a tool for conservation.Environmental monitoring and assessment · 2026Review
- Anti-aging effects of the adrenal androgens dehydroepiandrosterone and dehydroepiandrosterone sulfate: mechanisms of action and beneficial effects in older people.Endocrine journal · 2026Review
- DHEA and Cortisol in Rainbow Trout (Animals : an open access journal from MDPI · 2025Article
- Lack of effect of short-term DHEA supplementation on the perimenopausal ovary†.Biology of reproduction · 2020Article
- Acute Myocardial Infarction in a Young Bodybuilder: A Case Report and Review of the Literature.The American journal of case reports · 2020Review
- Effect of short-term DHEA supplementation on serum and hippocampal estrogen concentrations in perimenopausal female rhesus macaques.Neurobiology of aging · 2017Article
- Effect of caloric restriction on plasma melatonin levels in aged rhesus macaques.Neurobiology of aging · 2017Article
- Daily Rhythm in Plasma N-acetyltryptamine.Journal of biological rhythms · 2017Article
- Cognition in aged rhesus monkeys: effect of DHEA and correlation with steroidogenic gene expression.Genes, brain, and behavior · 2017Article
- Effects of chronic alcohol consumption on neuronal function in the non-human primate BNST.Addiction biology · 2016Article
- Contributions of Nonhuman Primates to Research on Aging.Veterinary pathology · 2016Review
- Editorial: From sex differences in neuroscience to a neuroscience of sex differences: new directions and perspectives.Frontiers in neuroscience · 2015Article
- Effects of Age and Estradiol on Gene Expression in the Rhesus Macaque Hypothalamus.Neuroendocrinology · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The adrenal steroid dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are two of the most abundant hormones in the human circulation. Furthermore, they are released in a circadian pattern and show a marked age-associated decline. Adult levels of DHEA and DHEAS are significantly higher in males than in females, but the reason for this sexual dimorphism is unclear. In the present study, we administered supplementary androgens [DHEA, testosterone and 5α-dihydrotestosterone (DHT)] to aged male rhesus macaques (Macaca mulatta). While this paradigm increased circulating DHEAS immediately after DHEA administration, an increase was also observed following either testosterone or DHT administration, resulting in hormonal profiles resembling levels observed in young males in terms of both amplitude and circadian pattern. This stimulatory effect was limited to DHEAS, as an increase in circulating cortisol was not observed. Taken together, these data demonstrate an influence of the hypothalamo-pituitary-testicular axis on adrenal function in males, possibly by sensitizing the zona reticularis to the stimulating action of adrenocorticopic hormone. This represents a plausible mechanism to explain sex differences in circulating DHEA and DHEAS levels, and may have important implications in the development of hormone therapies designed for elderly men and women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.