ReviewFrontiers in endocrinology2014
Transport of thyroid hormone in brain.
Review in Frontiers in endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 103 citations in OpenAlex.
- Multiscale characterization and distribution of the thyroid hormone transporter MCT8 in the adult and aged human brain.Acta neuropathologica communications · 2026Article
- Maternal Thyroid Function During Pregnancy and Early Adolescent Regional Differences in Cerebral Gray Matter Morphology.The Journal of clinical endocrinology and metabolism · 2026Article
- Updated consumer risk assessment of fluoride in food and drinking water including the contribution from other sources of oral exposure.EFSA journal. European Food Safety Authority · 2025Article
- Risks to human and animal health from the presence of bromide in food and feed.EFSA journal. European Food Safety Authority · 2025Article
- Reversible splenial lesion syndrome associated with Graves' disease and hepatic dysfunction: a case report.Frontiers in neuroscience · 2025Article
- Spatiotemporal expression of thyroid hormone transporter MCT8 and THRA mRNA in human cerebral organoids recapitulating first trimester cortex development.Scientific reports · 2024Article
- Loss of SLC30A10 manganese transporter alters expression of neurotransmission genes and activates hypoxia-inducible factor signaling in mice.Metallomics : integrated biometal science · 2024Article
- Factors and Mechanisms of Thyroid Hormone Activity in the Brain: Possible Role in Recovery and Protection.Biomolecules · 2024Review
- Neurovascular unit disruption and blood-brain barrier leakage in MCT8 deficiency.Fluids and barriers of the CNS · 2023Article
- Distribution of Monocarboxylate Transporters in Brain and Choroid Plexus Epithelium.Pharmaceutics · 2023Review
- Thyroid Axis and Vestibular Physiopathology: From Animal Model to Pathology.International journal of molecular sciences · 2023Review
- Role and Clinical Significance of Monocarboxylate Transporter 8 (MCT8) During Pregnancy.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- Establishing Patient-Centered Outcomes for MCT8 Deficiency: Stakeholder Engagement and Systematic Literature Review.Neuropsychiatric disease and treatment · 2023Article
- What is thyroid function in your just-diagnosed cancer patient?Frontiers in endocrinology · 2023Article
- Epigenetic developmental programming and intergenerational effects of thyroid hormones.Vitamins and hormones · 2023Review
- IGSF1 Deficiency Leads to Reduced TSH Production Independent of Alterations in Thyroid Hormone Action in Male Mice.Endocrinology · 2022Article
- Thyroxine and Thyroid-Stimulating Hormone in Own Mother's Milk, Donor Milk, and Infant Formula.Life (Basel, Switzerland) · 2022Article
- Article
- Role of thyroid hormones in craniofacial development.Nature reviews. Endocrinology · 2020Review
- Steroid Hormone Entry into the Brain Requires a Membrane Transporter in Drosophila.Current biology : CB · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thyroid hormone (TH) transport into the brain is not only pivotal for development and differentiation, but also for maintenance and regulation of adult central nervous system (CNS) function. In this review, we highlight some key factors and structures regulating TH uptake and distribution. Serum TH binding proteins play a major role for the availability of TH since only free hormone concentrations may dictate cellular uptake. One of these proteins, transthyretin is also present in the cerebrospinal fluid (CSF) after being secreted by the choroid plexus. Entry routes into the brain like the blood-brain-barrier (BBB) and the blood-CSF-barrier will be explicated regarding fetal and adult status. Recently identified TH transmembrane transporters (THTT) like monocarboxylate transporter 8 (Mct8) play a major role in uptake of TH across the BBB but as well in transport between cells like astrocytes and neurons within the brain. Species differences in transporter expression will be presented and interference of TH transport by endogenous and exogenous compounds including endocrine disruptors and drugs will be discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.