Evidence map›Paper›PMID 25009530›Full record

ReviewFrontiers in neurology2014

Functional magnetic resonance imaging in narcolepsy and the kleine-levin syndrome.

Maria Engström, Tove Hallböök, Attila Szakacs, Thomas Karlsson, Anne-Marie Landtblom

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05443373 (A Multi-Signal Based Monitoring System for CNS Hypersomnias), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05443373 unknown statusnot on this mapstarted 2020, after this paper: background citation

A Multi-Signal Based Monitoring System for CNS Hypersomnias : A 10-year Longitudinal Study

TypeobservationalSponsorChang Gung Memorial HospitalRan2020 to 2023Enrolled600ConditionsHypersomnia
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Kleine-Levin syndrome: clues to aetiology.Sleep & breathing = Schlaf & Atmung · 2018
    Review
  9. Article
  10. Brain MRI findings in patients with idiopathic hypersomnia.Clinical neurology and neurosurgery · 2017
    Article
  11. Article
  12. Kleine-Levin Syndrome.Current treatment options in neurology · 2016
    Review
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Maria EngströmDivision of Radiological Sciences, Department of Medical and Health Sciences (IMH), Linköping University , Linköping , Sweden ; Center for Medical Image Science and Visualization (CMIV), Linköping University , Linköping , Sweden.
Tove HallböökDepartment of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden.
Attila SzakacsDepartment of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden ; Department of Pediatrics, Halmstad County Hospital , Halmstad , Sweden.
Thomas KarlssonCenter for Medical Image Science and Visualization (CMIV), Linköping University , Linköping , Sweden ; Division of Disability Research and Linnaeus Centre HEAD, Department of Behavioral Science and Learning, Linköping University , Linköping , Sweden.
Anne-Marie LandtblomCenter for Medical Image Science and Visualization (CMIV), Linköping University , Linköping , Sweden ; Department of Neurology, Department of Clinical and Experimental Medicine (IKE), Linköping University , Linköping , Sweden ; Department of Medical Specialist, Department of Medicine and Health Sciences, Linköping University , Motala , Sweden ; Department of Neuroscience, Uppsala University , Uppsala , Sweden.
Linköping University · SEUniversity of Gothenburg · SEUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This work aims at reviewing the present state of the art when it comes to understanding the pathophysiology of narcolepsy and the Kleine-Levin syndrome (KLS) from a neuroimaging point of view. This work also aims at discussing future perspectives of functional neuroimaging in these sleep disorders. We focus on functional magnetic resonance imaging (fMRI), which is a technique for in vivo measurements of brain activation in neuronal circuitries under healthy and pathological conditions. fMRI has significantly increased the knowledge on the affected neuronal circuitries in narcolepsy and the Kleine-Levin syndrome. It has been shown that narcolepsy is accompanied with disturbances of the emotional and the closely related reward systems. In the Kleine Levin syndrome, fMRI has identified hyperactivation of the thalamus as a potential biomarker that could be used in the diagnostic procedure. The fMRI findings in both narcolepsy and the Kleine-Levin syndrome are in line with previous structural and functional imaging studies. We conclude that fMRI in combination with multi-modal imaging can reveal important details about the pathophysiology in narcolepsy and the Kleine-Levin syndrome. In the future, fMRI possibly gives opportunities for diagnostic support and prediction of treatment response in individual patients.

Indexed as

ascending arousal systemfunctional magnetic resonance imaginghypersomniahypothalamusKleine–Levin syndromenarcolepsysleepthalamus

Identifiers

PMID25009530
PMCPMC4069720
OpenAlexW2150035970

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.