Evidence map›Paper›PMID 25009500›Full record

ReviewFrontiers in physiology2014

Down-regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5: a novel mechanism for inhibition of cellular proliferation and insulin secretion by somatostatin.

Guisheng Zhou, Jim Sinnett-Smith, Shi-He Liu, Juehua Yu, James Wu, Robbi Sanchez, Stephen J Pandol, Ravinder Abrol, John Nemunaitis, Enrique Rozengurt and 1 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Guisheng ZhouDivision of General Surgery, Department of Surgery, David Geffen School of Medicine at University of California Los Angeles, CA, USA ; CURE: Digestive Disease Research Center, David Geffen School of Medicine at University of California Los Angeles, CA, USA.
Jim Sinnett-SmithCURE: Digestive Disease Research Center, David Geffen School of Medicine at University of California Los Angeles, CA, USA ; Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, CA, USA.
Shi-He LiuDivision of General Surgery, Department of Surgery, David Geffen School of Medicine at University of California Los Angeles, CA, USA.
Juehua YuDivision of General Surgery, Department of Surgery, David Geffen School of Medicine at University of California Los Angeles, CA, USA.
James WuDivision of General Surgery, Department of Surgery, David Geffen School of Medicine at University of California Los Angeles, CA, USA.
Robbi SanchezDivision of General Surgery, Department of Surgery, David Geffen School of Medicine at University of California Los Angeles, CA, USA.
Stephen J PandolCURE: Digestive Disease Research Center, David Geffen School of Medicine at University of California Los Angeles, CA, USA ; Department of Medicine at Cedars Sinai Medical Center Los Angeles, CA, USA ; Veterans Affairs Los Angeles, CA, USA.
Ravinder AbrolMaterials and Process Simulation Center, California Institute of Technology Pasadena, CA, USA.
John NemunaitisGradalis, Inc., Dallas, TX, USA ; Mary Crowley Cancer Research Centers Dallas, TX, USA.
Enrique RozengurtCURE: Digestive Disease Research Center, David Geffen School of Medicine at University of California Los Angeles, CA, USA ; Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, CA, USA.
F Charles BrunicardiDivision of General Surgery, Department of Surgery, David Geffen School of Medicine at University of California Los Angeles, CA, USA ; CURE: Digestive Disease Research Center, David Geffen School of Medicine at University of California Los Angeles, CA, USA.
University of California, Los Angeles · USCalifornia Institute of Technology · USCedars-Sinai Medical Center · USGradalis (United States) · US

Funding

Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 1990 to 2019
$18.0M
Targeting diet-induced promotion of Kras-initiated pancreatic adenocarcinomaP01CA163200 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PANDOL, STEPHEN J. · 2012 to 2016
$6.2M
PDX-1 is a Therapeutic Target for Pancreatic CancerR01CA095731 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BRUNICARDI, FRANCIS CHARLES · 2002 to 2012
$2.6M
Intraislet Communication in Surgically-Altered PancreasR01DK046441 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI BRUNICARDI, FRANCIS CHARLES · 1998 to 2007
$1.9M
NCI NIH HHS P01 CA163200NCI NIH HHS R01 CA095731NIDDK NIH HHS P30 DK041301NIDDK NIH HHS R01 DK046441
6 · The paper itself

Abstract

Somatostatin (SST) is a regulatory peptide and acts as an endogenous inhibitory regulator of the secretory and proliferative responses of target cells. SST's actions are mediated by a family of seven transmembrane domain G protein-coupled receptors that comprise five distinct subtypes (SSTR1-5). SSTR5 is one of the major SSTRs in the islets of Langerhans. Homeodomain-containing transcription factor pancreatic and duodenal homeobox-1 (PDX-1) is essential for pancreatic development, β cell differentiation, maintenance of normal β cell functions in adults and tumorigenesis. Recent studies show that SSTR5 acts as a negative regulator for PDX-1 expression and that SSTR5 mediates somatostatin's inhibitory effect on cell proliferation and insulin expression/excretion through down-regulating PDX-1 expression. SSTR5 exerts its inhibitory effect on PDX-1 expression at both the transcriptional level by down-regulating PDX-1 mRNA and the post-translational level by enhancing PDX-1 ubiquitination. Identification of PDX-1 as a transcriptional target for SSTR5 may help in guiding the choice of therapeutic cancer treatments.

Indexed as

G protein-coupled receptorspancreatic and duodenal homeobox-1single nucleotide polymorphismssomatostatinsomatostatin receptor

Identifiers

PMID25009500
PMCPMC4069483
OpenAlexW2018327304

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.