ArticleFrontiers in aging neuroscience2014
Human longevity is associated with regular sleep patterns, maintenance of slow wave sleep, and favorable lipid profile.
Article in Frontiers in aging neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Pooled it
- Effects of HIIT and MIIT Suspension Training Programs on Sleep Quality and Fatigue in Older Adults: Randomized Controlled Clinical Trial.International journal of environmental research and public health · 2021Trial
- A familial natural short sleep mutation iniScience · 2025Article
- How Important Are Dietary Habits Compared to Other Factors for Sleep Quality?-An Analysis Using Data from a Specific Region in Japan.Nutrients · 2025Article
- Objective sleep monitoring at home in older adults: A scoping review.Journal of sleep research · 2025Article
- Advances in Longevity: The Intersection of Regenerative Medicine and Cosmetic Dermatology.Journal of cosmetic dermatology · 2025Review
- Explanatory AI Predicts the Diet Adopted Based on Nutritional and Lifestyle Habits in the Spanish Population.European journal of investigation in health, psychology and education · 2025Article
- Mechanisms, consequences and role of interventions for sleep deprivation: Focus on mild cognitive impairment and Alzheimer's disease in elderly.Ageing research reviews · 2024Review
- Sex and Sleep Disruption as Contributing Factors in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2024Review
- Sleep, Stress, and Cardiometabolic Health in Women of Childbearing Age with Overweight and Obesity.Women's health reports (New Rochelle, N.Y.) · 2024Article
- Neural ageing and synaptic plasticity: prioritizing brain health in healthy longevity.Frontiers in aging neuroscience · 2024Review
- Bedtime regularity predicts positive affect among veterans with posttraumatic stress disorder: an ecological momentary assessment study.BMC psychiatry · 2023Article
- Variability in Sleep Duration and Biomarkers of Cardiovascular Disease Across the Menstrual Cycle.American journal of epidemiology · 2023Article
- Sleep profile in a population of community-dwelling nonagenarians: data from the Mugello study.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2023Article
- Effect of Familial Longevity on Frailty and Sarcopenia: A Case-Control Study.International journal of environmental research and public health · 2023Observational
- Non-Enzymatic Antioxidants against Alzheimer's Disease: Prevention, Diagnosis and Therapy.Antioxidants (Basel, Switzerland) · 2023Review
- Excessive daytime sleepiness is associated with impaired antibody response to influenza vaccination in older male adults.Frontiers in cellular and infection microbiology · 2023Article
- Environmental stressors, sleep, and a visit from St. Nicholas.Sleep advances : a journal of the Sleep Research Society · 2023Article
- Protocol for single case experimental design for yoga and sleep quality and inflammation: A two-hit model of sleep intervention.Contemporary clinical trials communications · 2022Article
- An aqueous extract of the brown algaAging · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Some individuals are able to successfully reach very old ages, reflecting higher adaptation against age-associated effects. Sleep is one of the processes deeply affected by aging; however few studies evaluating sleep in long-lived individuals (aged over 85) have been reported to date. The aim of this study was to characterize the sleep patterns and biochemical profile of oldest old individuals (N = 10, age 85-105 years old) and compare them to young adults (N = 15, age 20-30 years old) and older adults (N = 13, age 60-70 years old). All subjects underwent full-night polysomnography, 1-week of actigraphic recording and peripheral blood collection. Sleep electroencephalogram spectral analysis was also performed. The oldest old individuals showed lower sleep efficiency and REM sleep when compared to the older adults, while stage N3 percentage and delta power were similar across the groups. Oldest old individuals maintained strictly regular sleep-wake schedules and also presented higher HDL-cholesterol and lower triglyceride levels than older adults. The present study revealed novel data regarding specific sleep patterns and maintenance of slow wave sleep in the oldest old group. Taken together with the favorable lipid profile, these results contribute with evidence to the importance of sleep and lipid metabolism regulation in the maintenance of longevity in humans.
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Registered trials
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