ArticleWorld journal of gastroenterology2014
Effect of a high-fat diet in development of colonic adenoma in an animal model.
Article in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 50 citations in OpenAlex.
- The burden of colorectal cancer attributable to high body mass index in China: findings from 1990 to 2021 and prediction to 2035.International journal of colorectal disease · 2025Article
- Unraveling molecular interconnections and identifying potential therapeutic targets of significance in obesity-cancer link.Journal of the National Cancer Center · 2025Review
- Piperine inhibits the proliferation of colorectal adenocarcinoma by regulatingBiomolecules & biomedicine · 2025Article
- Article
- Role of Hydrogen Sulfide in Inflammatory Bowel Disease.Antioxidants (Basel, Switzerland) · 2023Review
- A lipid metabolism-related gene signature reveals dynamic immune infiltration of the colorectal adenoma-carcinoma sequence.Lipids in health and disease · 2023Article
- The Potential Chemopreventive Effect ofInternational journal of molecular sciences · 2023Article
- Maternal high-fat diet increases the susceptibility of offspring to colorectal cancer via the activation of intestinal inflammation.Frontiers in nutrition · 2023Review
- Ficus dubia latex extract prevent DMH-induced rat early colorectal carcinogenesis through the regulation of xenobiotic metabolism, inflammation, cell proliferation and apoptosis.Scientific reports · 2022Article
- Dietary Fat Intake andNutrients · 2022Article
- Secondary Bile Acids and Tumorigenesis in Colorectal Cancer.Frontiers in oncology · 2022Review
- High fat diet, gut microbiome and gastrointestinal cancer.Theranostics · 2021Review
- The Role of Dyslipidemia in Colitis-Associated Colorectal Cancer.Journal of oncology · 2021Review
- Transcriptomic and Proteomic Study on the High-Fat Diet Combined With AOM/DSS-Induced Adenomatous Polyps in Mice.Frontiers in oncology · 2021Article
- Dietary habits affect fatty acid composition of visceral adipose tissue in subjects with colorectal cancer or obesity.European journal of nutrition · 2020Article
- In Vitro and In Vivo Nutraceutical Characterization of Two Chickpea Accessions: Differential Effects on Hepatic Lipid Over-Accumulation.Antioxidants (Basel, Switzerland) · 2020Article
- Biochemical and molecular aspects of 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis: a review.Toxicology research · 2020Review
- Effects of high-fat diet-induced adipokines and cytokines on colorectal cancer development.FEBS open bio · 2019Article
- Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the effect of a high-fat diet in the formation of the precursors of colorectal cancer using an animal model.
methodsWistar rats were divided into two groups that were fed either a high-fat diet (HFD) or a normal-fat diet (ND), and 1,2-dimethylhydrazine was administered at a dose of 40 mg/kg for 10 wk. The body weight/liver weight/epididymal fat weight were recorded after rats were sacrificed, and the formation of colonic adenoma was also observed. The levels of insulin, leptin, tumor necrosis factor (TNF)-α, insulin-like growth factor (IGF)-1 and triglycerides were determined by enzyme-linked immunosorbent assay in order to compare the altered levels of biochemical indices and inflammatory cytokines in the serum between rats fed an ND and HFD. Cell proliferation activity (Ki-67) was determined by immunohistochemical analysis. Western blot and immunofluorescence staining were used to examine the expression of proliferating cell nuclear antigen (PCNA), cyclooxygenase (COX)-2, cyclin D1, β-catenin and nuclear factor (NF)-κB proteins in the adenoma and comparative control tissues.
resultsThe number of colonic adenomas and the colonic epithelial Ki-67 were significantly higher in the HFD group than in the ND group. The HFD group also had increased body weight, liver weight and epididymal fat weight, which were associated with increased levels of serum insulin, leptin, TNF-α, IGF-1 and triglycerides. HFD induced upregulation of PCNA, COX-2, cyclin D1, β-catenin and NF-κB proteins, as revealed by Western blot and immunofluorescence staining.
conclusionHFD promotes the formation of colonic adenoma through inflammation, metabolic abnormalities, and increases cell cycle progression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.