ArticleIntegrative and comparative biology2014
Specification to biomineralization: following a single cell type as it constructs a skeleton.
Article in Integrative and comparative biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- PFAS compounds PFOA and Gen X are teratogenic to sea urchin embryos.Developmental biology · 2025Article
- Localization and origins of juvenile skeletogenic cells in the sea urchin Lytechinuspictus.Developmental biology · 2024Article
- ICAT: a novel algorithm to robustly identify cell states following perturbations in single-cell transcriptomes.Bioinformatics (Oxford, England) · 2023Article
- De novo genome assembly and annotation of Holothuria scabra (Jaeger, 1833) from nanopore sequencing reads.Genes & genomics · 2022Article
- Gastrulation in the sea urchin.Current topics in developmental biology · 2020Review
- Developmental effector gene regulation: Multiplexed strategies for functional analysis.Developmental biology · 2019Article
- Cdc42 controls primary mesenchyme cell morphogenesis in the sea urchin embryo.Developmental biology · 2018Article
- The sea cucumber genome provides insights into morphological evolution and visceral regeneration.PLoS biology · 2017Article
- Function and regulation of microRNA-31 in development and disease.Molecular reproduction and development · 2016Review
- Developmental gene regulatory networks in sea urchins and what we can learn from them.F1000Research · 2016Review
- microRNA-31 modulates skeletal patterning in the sea urchin embryo.Development (Cambridge, England) · 2015Article
- Evolutionary rewiring of gene regulatory network linkages at divergence of the echinoid subclasses.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The sea urchin larva is shaped by a calcite endoskeleton. That skeleton is built by 64 primary mesenchyme cells (PMCs) in Lytechinus variegatus. The PMCs originate as micromeres due to an unequal fourth cleavage in the embryo. Micromeres are specified in a well-described molecular sequence and enter the blastocoel at a precise time using a classic epithelial-mesenchymal transition. To make the skeleton, the PMCs receive signaling inputs from the overlying ectoderm, which provides positional information as well as control of the growth of initial skeletal tri-radiates. The patterning of the skeleton is the result both of autonomous inputs from PMCs, including production of proteins that are included in the skeletal matrix, and of non-autonomous dynamic information from the ectoderm. Here, we summarize the wealth of information known about how a PMC contributes to the skeletal structure. The larval skeleton is a model for understanding how information encoded in DNA is translated into a three-dimensional crystalline structure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.