ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Dissecting the signaling mechanisms underlying recognition and preference of food odors.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
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- Loss of neuropeptidergic regulation of cholinergic transmission induces homeostatic compensation in muscle cells to preserve synaptic strength.PLoS biology · 2025Article
- Serotonin deficiency from constitutive SKN-1 activation drives pathogen apathy.Nature communications · 2024Article
- Mitochondrial energy state controls AMPK-mediated foraging behavior inScience advances · 2024Article
- Chemical basis of microbiome preference in the nematode C. elegans.Scientific reports · 2024Article
- Worms love Coffee too! Characterizing the neural substrates that regulate odor-guided responses to coffee.microPublication biology · 2024Article
- Chemotaxis ofMicroorganisms · 2023Article
- Article
- The role of food odor in invertebrate foraging.Genes, brain, and behavior · 2022Review
- Food preference acquired by social transmission is altered by the absence of the olfactory marker protein in mice.Frontiers in nutrition · 2022Article
- Worms like catnip too! Identification of a new odor attractant inmicroPublication biology · 2022Article
- Article
- Chemosensory signal transduction in Caenorhabditis elegans.Genetics · 2021Review
- Molecular Strategies for Intensity-Dependent Olfactory Processing inFrontiers in molecular neuroscience · 2021Article
- Worms avoid a cat sensed repellent.microPublication biology · 2020Article
- Bacterial diets differentially alter lifespan and healthspan trajectories in C. elegans.Communications biology · 2020Article
- The role of carbon dioxide in nematode behaviour and physiology.Parasitology · 2020Review
- Neuronal GPCR NPR-8 regulatesScience advances · 2019Article
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Authors and funding
7 authors.
Funding
Abstract
Food is critical for survival. Many animals, including the nematode Caenorhabditis elegans, use sensorimotor systems to detect and locate preferred food sources. However, the signaling mechanisms underlying food-choice behaviors are poorly understood. Here, we characterize the molecular signaling that regulates recognition and preference between different food odors in C. elegans. We show that the major olfactory sensory neurons, AWB and AWC, play essential roles in this behavior. A canonical Gα-protein, together with guanylate cyclases and cGMP-gated channels, is needed for the recognition of food odors. The food-odor-evoked signal is transmitted via glutamatergic neurotransmission from AWC and through AMPA and kainate-like glutamate receptor subunits. In contrast, peptidergic signaling is required to generate preference between different food odors while being dispensable for the recognition of the odors. We show that this regulation is achieved by the neuropeptide NLP-9 produced in AWB, which acts with its putative receptor NPR-18, and by the neuropeptide NLP-1 produced in AWC. In addition, another set of sensory neurons inhibits food-odor preference. These mechanistic logics, together with a previously mapped neural circuit underlying food-odor preference, provide a functional network linking sensory response, transduction, and downstream receptors to process complex olfactory information and generate the appropriate behavioral decision essential for survival.
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