ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Parallel functional reorganizations of somatosensory areas 3b and 1, and S2 following spinal cord injury in squirrel monkeys.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- AI-assisted 3D analysis of grasping and reaching behavior of squirrel monkeys during recovery from cervical spinal cord injury.Behavioural brain research · 2025Article
- Longitudinal multiparametric MRI of traumatic spinal cord injury in animal models.Magnetic resonance imaging · 2023Review
- Machine-learning-based video analysis of grasping behavior during recovery from cervical spinal cord injury.Behavioural brain research · 2023Article
- Differential Recovery of Submodality Touch Neurons and Interareal Communication in Sensory Input-Deprived Area 3b and S2 Cortices.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Preserved cortical somatotopic and motor representations in tetraplegic humans.Current opinion in neurobiology · 2022Review
- Longitudinal fMRI measures of cortical reactivation and hand use with and without training after sensory loss in primates.NeuroImage · 2021Article
- Corticocuneate projections are altered after spinal cord dorsal column lesions in New World monkeys.The Journal of comparative neurology · 2021Article
- Sensory Circuit Remodeling and Movement Recovery After Spinal Cord Injury.Frontiers in neuroscience · 2021Review
- Reorganization of Higher-Order Somatosensory Cortex After Sensory Loss from Hand in Squirrel Monkeys.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Neuromodulation of sensory networks in monkey brain by focused ultrasound with MRI guidance and detection.Scientific reports · 2018Article
- Correlated Disruption of Resting-State fMRI, LFP, and Spike Connectivity between Area 3b and S2 following Spinal Cord Injury in Monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Biophysical and neural basis of resting state functional connectivity: Evidence from non-human primates.Magnetic resonance imaging · 2017Review
- Effects of isoflurane anesthesia on resting-state fMRI signals and functional connectivity within primary somatosensory cortex of monkeys.Brain and behavior · 2016Article
- Spatiotemporal trajectories of reactivation of somatosensory cortex by direct and secondary pathways after dorsal column lesions in squirrel monkeys.NeuroImage · 2016Article
- Intracortical connections are altered after long-standing deprivation of dorsal column inputs in the hand region of area 3b in squirrel monkeys.The Journal of comparative neurology · 2016Article
- Injury alters intrinsic functional connectivity within the primate spinal cord.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Bidirectional and state-dependent modulation of brain activity by transcranial focused ultrasound in non-human primates.Brain stimulationArticle
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4 authors at 2 institutions in 1 country.
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Abstract
Multiple somatosensory cortices of adult primates reorganize following spinal cord injury, but little is known about the temporal dynamics and inter-areal differences of the reorganization. Using longitudinal high-resolution fMRI in combination with microelectrode recordings and tracer histology, we previously illustrated a two-phase dynamic spatial reorganization of digit representations in area 3b within weeks after a unilateral lesion of the dorsal column in squirrel monkeys (Chen et al., 2012). Here we report that higher-order area 1 and secondary somatosensory cortex (S2) underwent similar spatial reorganizations, which were characterized by shifted and expanded digit activations at week 4 after lesion, which then shifted back and contracted by week 8. In addition, the responsiveness of areas 3b and 1, and S2, as measured by the magnitude of the BOLD signal change to tactile stimuli, was reduced markedly at 4 weeks and then recovered to ~50% of the prelesion level at 8 weeks, a time when behavioral recovery was complete, as assessed by successful food retrieval rates. Across animals, the extents of spatial reorganizations and changes in cortical responsiveness and activation sizes in all three areas were correlated with the degree of afferent disruption. In summary, our data show that more severe afferent disruption was associated with greater cortical plasticity and behavioral impairment. Reorganization that occurred in area 3b, area 1, and S2 were similar across most measures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.