ArticleG3 (Bethesda, Md.)2014
Genetic basis for Saccharomyces cerevisiae biofilm in liquid medium.
Article in G3 (Bethesda, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Sdd3 regulates the biofilm formation ofmBio · 2025Article
- F-box protein Fbx23 acts as a transcriptional coactivator to recognize and activate transcription factor Ace1.PLoS genetics · 2025Article
- Biotechnological applications of biofilms formed by osmotolerant and halotolerant yeasts.Applied microbiology and biotechnology · 2023Review
- Regulatory role of Mss11 inFrontiers in cellular and infection microbiology · 2023Article
- Tec1 and Ste12 transcription factors play a role in adaptation to low pH stress and biofilm formation in the human opportunistic fungal pathogen Candida glabrata.International microbiology : the official journal of the Spanish Society for Microbiology · 2022Article
- Cell Cycle Progression Influences Biofilm Formation in Saccharomyces cerevisiae 1308.Microbiology spectrum · 2022Article
- Formation and characterization of biofilms formed by salt-tolerant yeast strains in seawater-based growth medium.Applied microbiology and biotechnology · 2021Article
- AJournal of fungi (Basel, Switzerland) · 2021Article
- Spatially structured yeast communities: Understanding structure formation and regulation with omics tools.Computational and structural biotechnology journal · 2021Review
- Simple Carbohydrate Derivatives Diminish the Formation of Biofilm of the Pathogenic YeastAntibiotics (Basel, Switzerland) · 2019Article
- Multicellular group formation in Saccharomyces cerevisiae.Proceedings. Biological sciences · 2019Article
- Disadvantages and benefits of evolved unicellularity versus multicellularity in budding yeast.Ecology and evolution · 2019Article
- Filamentation Regulatory Pathways Control Adhesion-Dependent Surface Responses in Yeast.Genetics · 2019Article
- Variation in Filamentous Growth and Response to Quorum-Sensing Compounds in Environmental Isolates ofG3 (Bethesda, Md.) · 2019Article
- The use of polyhydroxylated carboxylic acids and lactones to diminish biofilm formation of the pathogenic yeastRSC advances · 2019Article
- Aggregate Filamentous Growth Responses in Yeast.mSphere · 2019Article
- Cell Wall Surface Properties ofFrontiers in microbiology · 2019Article
- Article
- High-resolution mapping ofProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Clonal yeast biofilms can reap competitive advantages through cell differentiation without being obligatorily multicellular.Proceedings. Biological sciences · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biofilm-forming microorganisms switch between two forms: free-living planktonic and sessile multicellular. Sessile communities of yeast biofilms in liquid medium provide a primitive example of multicellularity and are clinically important because biofilms tend to have other growth characteristics than free-living cells. We investigated the genetic basis for yeast, Saccharomyces cerevisiae, biofilm on solid surfaces in liquid medium by screening a comprehensive deletion mutant collection in the Σ1278b background and found 71 genes that were essential for biofilm development. Quantitative northern blots further revealed that AIM1, ASG1, AVT1, DRN1, ELP4, FLO8, FMP10, HMT1, KAR5, MIT1, MRPL32, MSS11, NCP1, NPR1, PEP5, PEX25, RIM8, RIM101, RGT1, SNF8, SPC2, STB6, STP22, TEC1, VID24, VPS20, VTC3, YBL029W, YBL029C-A, YFL054C, YGR161W-C, YIL014C-A, YIR024C, YKL151C, YNL200C, YOR034C-A, and YOR223W controlled biofilm through FLO11 induction. Almost all deletion mutants that were unable to form biofilms in liquid medium also lost the ability to form surface-spreading biofilm colonies (mats) on agar and 69% also lost the ability to grow invasively. The protein kinase A isoform Tpk3p functioned specifically in biofilm and mat formation. In a tpk3 mutant, transcription of FLO11 was induced three-fold compared with wild-type, but biofilm development and cell-cell adhesion was absent, suggesting that Tpk3p regulates FLO11 positive posttranscriptionally and negative transcriptionally.The study provides a resource of biofilm-influencing genes for additional research on biofilm development and suggests that the regulation of FLO11 is more complex than previously anticipated.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.