ArticleGenetics2014
Unraveling genomic complexity at a quantitative disease resistance locus in maize.
Article in Genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Three-dimensional infection network analysis in maize reveals variation in fungal colonization associated with lesion phenotypes.Scientific reports · 2026Article
- Experimental evaluation of effectiveness of genomic selection for resistance to northern corn leaf blight in maize.Journal of applied genetics · 2025Article
- Identification and fine-mapping ofMolecular breeding : new strategies in plant improvement · 2025Article
- A maize near-isogenic line population designed for gene discovery and characterization of allelic effects.The Plant journal : for cell and molecular biology · 2025Article
- Unveiling the underlying complexities in breeding for disease resistance in crop plants: review.Frontiers in plant science · 2025Review
- Genetic dissection of resistance to Phytophthora sojae using genome-wide association and linkage analysis in soybean [Glycine max (L.) Merr.].TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- A combination of joint linkage and genome-wide association study reveals putative candidate genes associated with resistance to northern corn leaf blight in tropical maize.Frontiers in plant science · 2024Article
- Brown midrib mutant and genome-wide association analysis uncover lignin genes for disease resistance in maize.The plant genome · 2023Article
- Inhibition of ethylene involved in resistance toFrontiers in plant science · 2023Article
- Comparative transcriptome meta-analysis reveals a set of genes involved in the responses to multiple pathogens in maize.Frontiers in plant science · 2022Article
- High-resolution mapping reveals aFrontiers in plant science · 2022Article
- Genomics-Assisted Breeding for Quantitative Disease Resistances in Small-Grain Cereals and Maize.International journal of molecular sciences · 2020Review
- Genome-wide association studies in tropical maize germplasm reveal novel and known genomic regions for resistance to Northern corn leaf blight.Scientific reports · 2020Article
- Maize Introgression Library Provides Evidence for the Involvement ofG3 (Bethesda, Md.) · 2020Article
- Identification of Loci That Confer Resistance to Bacterial and Fungal Diseases of Maize.G3 (Bethesda, Md.) · 2020Article
- Genetic mapping of northern corn leaf blight-resistant quantitative trait loci in maize.Medicine · 2020Article
- Conserved defense responses between maize and sorghum to Exserohilum turcicum.BMC plant biology · 2020Article
- Genome-Wide Analysis and Prediction of Resistance to Goss's Wilt in Maize.The plant genome · 2019Article
- Increased experimental conditions and marker densities identified more genetic loci associated with southern and northern leaf blight resistance in maize.Scientific reports · 2018Article
- Navigating complexity to breed disease-resistant crops.Nature reviews. Genetics · 2018Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple disease resistance has important implications for plant fitness, given the selection pressure that many pathogens exert directly on natural plant populations and indirectly via crop improvement programs. Evidence of a locus conditioning resistance to multiple pathogens was found in bin 1.06 of the maize genome with the allele from inbred line "Tx303" conditioning quantitative resistance to northern leaf blight (NLB) and qualitative resistance to Stewart's wilt. To dissect the genetic basis of resistance in this region and to refine candidate gene hypotheses, we mapped resistance to the two diseases. Both resistance phenotypes were localized to overlapping regions, with the Stewart's wilt interval refined to a 95.9-kb segment containing three genes and the NLB interval to a 3.60-Mb segment containing 117 genes. Regions of the introgression showed little to no recombination, suggesting structural differences between the inbred lines Tx303 and "B73," the parents of the fine-mapping population. We examined copy number variation across the region using next-generation sequencing data, and found large variation in read depth in Tx303 across the region relative to the reference genome of B73. In the fine-mapping region, association mapping for NLB implicated candidate genes, including a putative zinc finger and pan1. We tested mutant alleles and found that pan1 is a susceptibility gene for NLB and Stewart's wilt. Our data strongly suggest that structural variation plays an important role in resistance conditioned by this region, and pan1, a gene conditioning susceptibility for NLB, may underlie the QTL.
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