ArticleCell reports2014
A role for RUNX3 in inflammation-induced expression of IL23A in gastric epithelial cells.
Article in Cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Lacticaseibacillus paracasei KBL382 contributes to the immunomodulation in THP-1 cells.Journal of microbiology (Seoul, Korea) · 2026Article
- Inflammatory factors collaboratively linkFrontiers in immunology · 2025Review
- Anti-Inflammatory Activity of Black Soldier Fly Oil Associated with Modulation of TLR Signaling: A Metabolomic Approach.International journal of molecular sciences · 2023Article
- RUNX3 in Stem Cell and Cancer Biology.Cells · 2023Review
- Gastric organoids: Advancing the study of H. pylori pathogenesis and inflammation.Helicobacter · 2022Review
- Inflammatory and mitogenic signals drive interleukin 23 subunit alpha (IL23A) secretion independent of IL12B in intestinal epithelial cells.The Journal of biological chemistry · 2020Article
- Immunological Aspects of the Tumor Microenvironment and Epithelial-Mesenchymal Transition in Gastric Carcinogenesis.International journal of molecular sciences · 2020Review
- Interleukin-23 engineering improves CAR T cell function in solid tumors.Nature biotechnology · 2020Article
- Using high-throughput sequencing to explore the anti-inflammatory effects of α-mangostin.Scientific reports · 2019Article
- RUNX family: Oncogenes or tumor suppressors (Review).Oncology reports · 2019Review
- Article
- Genome-Wide Association Study on Immunoglobulin G Glycosylation Patterns.Frontiers in immunology · 2018Article
- MiR-19 regulates the proliferation and invasion of glioma by RUNX3 via β-catenin/Tcf-4 signaling.Oncotarget · 2017Article
- RUNX3 is down-regulated in glioma by Myc-regulated miR-4295.Journal of cellular and molecular medicine · 2016Article
- The RUNX complex: reaching beyond haematopoiesis into immunity.Immunology · 2015Review
- The RUNX family: developmental regulators in cancer.Nature reviews. Cancer · 2015Review
- NF-κB signaling pathway confers neuroblastoma cells migration and invasion ability via the regulation of CXCR4.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
- Altered Transcriptional Control Networks with Trans-Differentiation of Isogenic Mutant-KRas NSCLC Models.Frontiers in oncology · 2014Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
RUNX3 functions as a tumor suppressor in the gastric epithelium, where its inactivation is frequently observed during carcinogenesis. We identified IL23A as a RUNX3 target gene in gastric epithelial cells. This was confirmed in a series of in vitro analyses in gastric epithelial cell lines. In elucidating the underlying regulatory network, we uncovered a prominent role for the TNF-α/NF-κB pathway in activating IL23A transcription. Moreover, the activating effect of TNF-α was markedly augmented by the infection of Helicobacter pylori, the primary cause of human gastritis. Of note, H. pylori utilized the CagA/SHP2 pathway to activate IL23A, as well as the induction of the NOD1 pathway by iE-DAP. Importantly, RUNX3 synergized strongly with these physiologically relevant stimuli to induce IL23A. Lastly, we present evidence for the secretion of IL23A by gastric epithelial cells in a form that is distinct from canonical IL-23 (IL23A/IL12B).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.