TH2 and Treg candidate genes in elephant shark.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

29 citing papers in PubMed.

1. An ancient evolutionary origin for IL-1 cytokines.Nature ecology & evolution · 2026
   Article
2. Ancient IL-6-STAT5 signaling orchestrates inflammation in jawless vertebrates.bioRxiv : the preprint server for biology · 2026
   Article
3. PD-1 is conserved from sharks to humans: new insights into PD-1, PD-L1, PD-L2, and SHP-2 evolution.Frontiers in immunology · 2025
   Article
4. Molecular cloning, expression analysis, and functional characterization of an interleukin-15 like gene in common carp (Frontiers in immunology · 2024
   Article
5. Organized B cell sites in cartilaginous fishes reveal the evolutionary foundation of germinal centers.Cell reports · 2023
   Article
6. Investigation of the Molecular Evolution of Treg Suppression Mechanisms Indicates a Convergent Origin.Current issues in molecular biology · 2023
   Article
7. CD4 and LAG-3 from sharks to humans: related molecules with motifs for opposing functions.Frontiers in immunology · 2023
   Article
8. Comprehensive Sequence Analysis of Parvalbumins in Fish and Their Comparison with Parvalbumins in Tetrapod Species.Biology · 2022
   Article
9. The whale shark genome reveals patterns of vertebrate gene family evolution.eLife · 2021
   Article
10. The Structure of a Peptide-Loaded Shark MHC Class I Molecule Reveals Features of the Binding between βJournal of immunology (Baltimore, Md. : 1950) · 2021
    Article
11. A method for making alignments of related protein sequences that share very little similarity; shark interleukin 2 as an example.Immunogenetics · 2021
    Review
12. Transcriptome sequencing supports a conservation of macrophage polarization in fish.Scientific reports · 2020
    Article
13. Ancient Cytokine Interleukin 15-Like (IL-15L) Induces a Type 2 Immune Response.Frontiers in immunology · 2020
    Article
14. Major Histocompatibility Complex (MHC) Genes and Disease Resistance in Fish.Cells · 2019
    Review
15. CD4: a vital player in the teleost fish immune system.Veterinary research · 2019
    Review
16. Discovery of All Three Types in Cartilaginous Fishes Enables Phylogenetic Resolution of the Origins and Evolution of Interferons.Frontiers in immunology · 2019
    Article
17. A Comparison of the Innate and Adaptive Immune Systems in Cartilaginous Fish, Ray-Finned Fish, and Lobe-Finned Fish.Frontiers in immunology · 2019
    Review
18. Phylotranscriptomics suggests the jawed vertebrate ancestor could generate diverse helper and regulatory T cell subsets.BMC evolutionary biology · 2018
    Article
19. A cold-blooded view of adaptive immunity.Nature reviews. Immunology · 2018
    Review
20. Evolution of Th2 responses: characterization of IL-4/13 in sea bass (Dicentrarchus labrax L.) and studies of expression and biological activity.Scientific reports · 2017
    Article

Corrections and comments

• Commented on by
  Venkatesh et al. reply.2014
• Comment on
  Elephant shark genome provides unique insights into gnathostome evolution.2014

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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