SynthesisNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2014
Vitamin D receptor polymorphisms and susceptibility to Parkinson's disease and Alzheimer's disease: a meta-analysis.
Synthesis in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
25 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Associations of vitamin D receptor polymorphisms with risk of Alzheimer's disease, Parkinson's disease, and mild cognitive impairment: a systematic review and meta-analysis.Frontiers in aging neuroscience · 2024Pooled it
- Vitamin D Receptor Gene Polymorphisms and Risk of Alzheimer Disease and Mild Cognitive Impairment: A Systematic Review and Meta-Analysis.Advances in nutrition (Bethesda, Md.) · 2021Pooled it
- The Correlation Between Vitamin D Receptor (VDR) Gene Polymorphisms and Autism: A Meta-analysis.Journal of molecular neuroscience : MN · 2020Pooled it
- Vitamin D receptor gene polymorphisms and the risk of Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2015Pooled it
- Bone health in Parkinson's disease: a comprehensive review of bone involvement and its pathophysiological mechanisms.Frontiers in medicine · 2025Review
- Review
- Significance of the Vitamin D Receptor on Crosstalk with Nuclear Receptors and Regulation of Enzymes and Transporters.The AAPS journal · 2022Review
- VDR Gene Polymorphisms and Cluster Headache Susceptibility: Case-Control Study in a Southeastern European Caucasian Population.Journal of molecular neuroscience : MN · 2022Article
- Gut feelings: the microbiota-gut-brain axis on steroids.American journal of physiology. Gastrointestinal and liver physiology · 2022Review
- Vitamin D Receptor Polymorphisms in Sex-Frailty Paradox.Nutrients · 2020Article
- Blood biomarkers with Parkinson's disease clusters and prognosis: The oxford discovery cohort.Movement disorders : official journal of the Movement Disorder Society · 2020Article
- A Review of the Relationship Between Vitamin D and Parkinson Disease Symptoms.Frontiers in neurology · 2020Review
- Amyloid Beta 1-42 Alters the Expression of miRNAs in Cortical Neurons.Journal of molecular neuroscience : MN · 2019Article
- Higher Vitamin D Levels Are Associated with Better Attentional Functions: Data from the NorCog Register.The journal of nutrition, health & aging · 2019Article
- Health Risks of Hypovitaminosis D: A Review of New Molecular Insights.International journal of molecular sciences · 2018Review
- Polymorphisms in Vitamin D Receptor Genes in Association with Childhood Autism Spectrum Disorder.Disease markers · 2018Article
- Vitamin D and Neurological Diseases: An Endocrine View.International journal of molecular sciences · 2017Review
- Vitamin D in the Parkinson Associated Risk Syndrome (PARS) study.Movement disorders : official journal of the Movement Disorder Society · 2017Observational
- Vitamin D receptor gene polymorphisms and cognitive decline in Parkinson's disease.Journal of the neurological sciences · 2016Article
- The Impact of Vitamin E and Other Fat-Soluble Vitamins on Alzheimer´s Disease.International journal of molecular sciences · 2016Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The goal of this study was to examine whether vitamin D receptor (VDR) polymorphisms are associated with susceptibility to Parkinson's disease (PD) and Alzheimer's disease (AD). A meta-analysis was performed to investigate the association between VDR FokI, BsmI, TaqI, ApaI, rs4334089, or rs11568820 polymorphism and susceptibility to PD or AD. Thirteen studies, including seven on PD and six on AD, were included in this meta-analysis. The meta-analysis revealed an association between the BB + Bb genotype and PD in the Asian population (OR 0.478, 95 % CI 0.259-0.884, p = 0.018). We also observed a significant association between PD and the FokI F allele (OR 1.413, 95 % CI 1.144-1.746, p = 0.001). Meta-analysis of the A allele, the AA vs. Aa + aa, and the AA vs. aa for the ApaI polymorphism revealed significant associations with AD (OR 0.729, 95 % CI 0.0.591-0.900, p = 0.034; OR 0.591, 95 % CI 0.431-0.810, p = 0.001; OR 0.580, 95 % CI 0.361-0.931, p = 0.024, respectively). This meta-analysis demonstrates that the VDR BsmI polymorphism is associated with PD susceptibility in Asians, and the FokI polymorphism is associated with PD. Furthermore, we identified associations between the VDR TaqI and ApaI polymorphisms and AD susceptibility.
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