ArticleJournal of neurophysiology2014
Intrinsic bursting of AII amacrine cells underlies oscillations in the rd1 mouse retina.
Article in Journal of neurophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed, 95 citations in OpenAlex.
- Dopamine suppresses pathological retinal oscillations and enhances the signal-to-noise ratio.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Population-level geometric filtering generates motion-coherence selectivity in the retina.Science advances · 2026Article
- Resting-state electroretinography reveals pathological retinal oscillations in retinitis pigmentosa mice and patients.Nature communications · 2026Article
- The iCre-DTA176 Mouse Exhibits Canonical Spontaneous Network Activity Associated With Retinal Degeneration.Investigative ophthalmology & visual science · 2026Article
- Impact of Aii Amacrine Cell Rewiring in a Pathoconnectome-Based Computational Model of Early Retinal Degeneration.bioRxiv : the preprint server for biology · 2026Article
- Afadin-deficient mouse retinas exhibit severe neuronal lamination defects but preserve visual functions.eLife · 2025Article
- A mechanism for pathological oscillations in mouse retinal ganglion cells in a model of night blindness.The Journal of general physiology · 2025Article
- Photoreceptor degeneration has heterogeneous effects on functional retinal ganglion cell types.The Journal of physiology · 2025Article
- Activation of Dopamine D1 Receptors at the Axon Initial Segment-Like Process of Retinal AII Amacrine Cells Modulates Action Potential Firing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Effects of taurine, brimonidine and betaxolol on oscillation modulation and stimulation efficiency in degenerated rd10 mouse retinas.Scientific reports · 2025Article
- Article
- Retinoic Acid-Dependent Loss of Synaptic Output from Bipolar Cells Impairs Visual Information Processing in Inherited Retinal Degeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Comparison of modulation efficiency between normal and degenerated primate retina.Frontiers in cell and developmental biology · 2024Article
- Vision-Dependent and -Independent Molecular Maturation of Mouse Retinal Ganglion Cells.Neuroscience · 2023Article
- A retinal origin of nystagmus-a perspective.Frontiers in ophthalmology · 2023Article
- Article
- Retinoic acid inhibitors mitigate vision loss in a mouse model of retinal degeneration.Science advances · 2022Article
- Stage-Dependent Changes of Visual Function and Electrical Response of the Retina in theFrontiers in cellular neuroscience · 2022Article
- Correlated Activity in the Degenerate Retina Inhibits Focal Response to Electrical Stimulation.Frontiers in cellular neuroscience · 2022Article
- Functional Availability of ON-Bipolar Cells in the Degenerated Retina: Timing and Longevity of an Optogenetic Gene Therapy.International journal of molecular sciences · 2021Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
In many forms of retinal degeneration, photoreceptors die but inner retinal circuits remain intact. In the rd1 mouse, an established model for blinding retinal diseases, spontaneous activity in the coupled network of AII amacrine and ON cone bipolar cells leads to rhythmic bursting of ganglion cells. Since such activity could impair retinal and/or cortical responses to restored photoreceptor function, understanding its nature is important for developing treatments of retinal pathologies. Here we analyzed a compartmental model of the wild-type mouse AII amacrine cell to predict that the cell's intrinsic membrane properties, specifically, interacting fast Na and slow, M-type K conductances, would allow its membrane potential to oscillate when light-evoked excitatory synaptic inputs were withdrawn following photoreceptor degeneration. We tested and confirmed this hypothesis experimentally by recording from AIIs in a slice preparation of rd1 retina. Additionally, recordings from ganglion cells in a whole mount preparation of rd1 retina demonstrated that activity in AIIs was propagated unchanged to elicit bursts of action potentials in ganglion cells. We conclude that oscillations are not an emergent property of a degenerated retinal network. Rather, they arise largely from the intrinsic properties of a single retinal interneuron, the AII amacrine cell.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.