ArticleAnalytical chemistry2014
Temperature-ramped (129)Xe spin-exchange optical pumping.
Article in Analytical chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Detection of the Carcinogen Benzo[Analytical chemistry · 2026Article
- Continuous Delivery of Hyperpolarized Xenon-129 Gas Using a "Stopped-Flow" Clinical-Scale Cryogen-Free Hyperpolarizer.Analytical chemistry · 2025Article
- Pilot Quality-Assurance Study of a Third-Generation Batch-Mode Clinical-Scale Automated Xenon-129 Hyperpolarizer.Molecules (Basel, Switzerland) · 2022Article
- Enabling Clinical Technologies for HyperpolarizedAngewandte Chemie (International ed. in English) · 2021Review
- In vivo methods and applications of xenon-129 magnetic resonance.Progress in nuclear magnetic resonance spectroscopy · 2021Review
- Infinite-order perturbative treatment for quantum evolution with exchange.Science advances · 2020Article
- High Xe density, high photon flux, stopped-flow spin-exchange optical pumping: Simulations versus experiments.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2020Article
- A pulse programmable parahydrogen polarizer using a tunable electromagnet and dual channel NMR spectrometer.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2017Article
- Electron microscopic observations of Rb particles and pitting inJournal of applied physics · 2017Article
- Depolarization of nuclear spin polarizedJournal of magnetic resonance (San Diego, Calif. : 1997) · 2017Article
- Generalizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange.The journal of physical chemistry. C, Nanomaterials and interfaces · 2017Article
- NMR Hyperpolarization Techniques of Gases.Chemistry (Weinheim an der Bergstrasse, Germany) · 2017Review
- NMR SLIC Sensing of Hydrogenation Reactions Using Parahydrogen in Low Magnetic Fields.The journal of physical chemistry. C, Nanomaterials and interfaces · 2016Article
- Open-Source Automated Parahydrogen Hyperpolarizer for Molecular Imaging Using (13)C Metabolic Contrast Agents.Analytical chemistry · 2016Article
- Dose and pulse sequence considerations for hyperpolarized (129)Xe ventilation MRI.Magnetic resonance imaging · 2015Article
- NMR hyperpolarization techniques for biomedicine.Chemistry (Weinheim an der Bergstrasse, Germany) · 2015Article
- In situ and ex situ low-field NMR spectroscopy and MRI endowed by SABRE hyperpolarization.Chemphyschem : a European journal of chemical physics and physical chemistry · 2014Article
- Propane-The journal of physical chemistry. C, Nanomaterials and interfaces · 2014Article
- Irreversible catalyst activation enables hyperpolarization and water solubility for NMR signal amplification by reversible exchange.The journal of physical chemistry. B · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
We describe temperature-ramped spin-exchange optical pumping (TR-SEOP) in an automated high-throughput batch-mode (129)Xe hyperpolarizer utilizing three key temperature regimes: (i) "hot"-where the (129)Xe hyperpolarization rate is maximal, (ii) "warm"-where the (129)Xe hyperpolarization approaches unity, and (iii) "cool"-where hyperpolarized (129)Xe gas is transferred into a Tedlar bag with low Rb content (<5 ng per ∼1 L dose) suitable for human imaging applications. Unlike with the conventional approach of batch-mode SEOP, here all three temperature regimes may be operated under continuous high-power (170 W) laser irradiation, and hyperpolarized (129)Xe gas is delivered without the need for a cryocollection step. The variable-temperature approach increased the SEOP rate by more than 2-fold compared to the constant-temperature polarization rate (e.g., giving effective values for the exponential buildup constant γSEOP of 62.5 ± 3.7 × 10(-3) min(-1) vs 29.9 ± 1.2 × 10(-3) min(-1)) while achieving nearly the same maximum %PXe value (88.0 ± 0.8% vs 90.1% ± 0.8%, for a 500 Torr (67 kPa) Xe cell loading-corresponding to nuclear magnetic resonance/magnetic resonance imaging (NMR/MRI) enhancements of ∼3.1 × 10(5) and ∼2.32 × 10(8) at the relevant fields for clinical imaging and HP (129)Xe production of 3 T and 4 mT, respectively); moreover, the intercycle "dead" time was also significantly decreased. The higher-throughput TR-SEOP approach can be implemented without sacrificing the level of (129)Xe hyperpolarization or the experimental stability for automation-making this approach beneficial for improving the overall (129)Xe production rate in clinical settings.
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Registered trials
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