ArticleBMC oral health2014
Genome wide association scan for chronic periodontitis implicates novel locus.
Article in BMC oral health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Pooled it
- Genome-wide association study of periodontal pocketing in Finnish adults.BMC oral health · 2021Pooled it
- What Is the Heritability of Periodontitis? A Systematic Review.Journal of dental research · 2019Pooled it
- Meta-analysis of genome-wide association studies of aggressive and chronic periodontitis identifies two novel risk loci.European journal of human genetics : EJHG · 2019Pooled it
- A Principled Framework for Mendelian Randomization in Oral Health Research.Journal of periodontal research · 2026Article
- Genetic Loci Associated With Periodontitis: The FinnGen Study Based on National Health Registers.Journal of clinical periodontology · 2025Article
- Article
- Replication of gene polymorphisms associated with periodontitis-related traits in an elderly cohort: the Washington Heights/Inwood Community Aging Project Ancillary Study of Oral Health.Journal of clinical periodontology · 2022Article
- Article
- Periodontal health and disease: The contribution of genetics.Periodontology 2000 · 2021Review
- Causal Association Between Periodontitis and Type 2 Diabetes: A Bidirectional Two-Sample Mendelian Randomization Analysis.Frontiers in genetics · 2021Article
- Impact of Liability to Periodontitis on Glycemic Control and Type II Diabetes Risk: A Mendelian Randomization Study.Frontiers in genetics · 2021Article
- Article
- Is periodontitis a risk factor for ischaemic stroke, coronary artery disease and subclinical atherosclerosis? A Mendelian randomization study.Atherosclerosis · 2020Article
- Genomics of periodontal disease and tooth morbidity.Periodontology 2000 · 2020Review
- Periodontal disease susceptible matrilines in the Cayo Santiago Macaca mulatta macaques.Journal of periodontal research · 2019Article
- Protocols, Methods, and Tools for Genome-Wide Association Studies (GWAS) of Dental Traits.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Family History of MI, Smoking, and Risk of Periodontal Disease.Journal of dental research · 2018Article
- Dental genetics in Brazil: Where we are.Molecular genetics & genomic medicine · 2018Article
- Common Polymorphisms in IFI16 and AIM2 Genes Are Associated With Periodontal Disease.Journal of periodontology · 2017Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
backgroundThere is evidence for a genetic contribution to chronic periodontitis. In this study, we conducted a genome wide association study among 866 participants of the University of Pittsburgh Dental Registry and DNA Repository, whose periodontal diagnosis ranged from healthy (N = 767) to severe chronic periodontitis (N = 99).
methodsGenotypingi of over half-million single nucleotide polymorphisms was determined. Analyses were done twice, first in the complete dataset of all ethnicities, and second including only samples defined as self-reported Whites. From the top 100 results, twenty single nucleotide polymorphisms had consistent results in both analyses (borderline p-values ranging from 1E-05 to 1E-6) and were selected to be tested in two independent datasets derived from 1,460 individuals from Porto Alegre, and 359 from Rio de Janeiro, Brazil. Meta-analyses of the Single nucleotide polymorphisms showing a trend for association in the independent dataset were performed.
resultsThe rs1477403 marker located on 16q22.3 showed suggestive association in the discovery phase and in the Porto Alegre dataset (p = 0.05). The meta-analysis suggested the less common allele decreases the risk of chronic periodontitis.
conclusionsOur data offer a clear hypothesis to be independently tested regarding the contribution of the 16q22.3 locus to chronic periodontitis.
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