ArticleMedical oncology (Northwood, London, England)2014
miR-129-1-3p inhibits cell migration by targeting BDKRB2 in gastric cancer.
Article in Medical oncology (Northwood, London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Review
- A panel based on three-miRNAs as diagnostic biomarker for prostate cancer.Frontiers in genetics · 2024Article
- Role of Some microRNA/ADAM Proteins Axes in Gastrointestinal Cancers as a Novel Biomarkers and Potential Therapeutic Targets-A Review.Current issues in molecular biology · 2023Review
- Atrophic gastritis and gastric cancer tissue miRNome analysis reveals hsa-miR-129-1 and hsa-miR-196a as potential early diagnostic biomarkers.World journal of gastroenterology · 2022Article
- MicroRNA-129-1-3p Represses the Progression of Triple-Negative Breast Cancer by Targeting the GRIN2D Gene.BioMed research international · 2022Article
- Gene network analysis to determine the effect of hypoxia-associated genes on brain damages and tumorigenesis using an avian model.Journal, genetic engineering & biotechnology · 2021Article
- Article
- Article
- Integrated bioinformatics analysis for the identification of potential key genes affecting the pathogenesis of clear cell renal cell carcinoma.Oncology letters · 2020Article
- c-Src promotes tumor progression through downregulation of microRNA-129-1-3p.Cancer science · 2020Article
- NORAD accelerates chemo-resistance of non-small-cell lung cancer via targeting at miR-129-1-3p/SOX4 axis.Bioscience reports · 2020Article
- MicroRNA-129-2-3p directly targets Wip1 to suppress the proliferation and invasion of intrahepatic cholangiocarcinoma.Journal of Cancer · 2020Article
- Article
- Identification and functional characterization of microRNAs reveal a potential role in gastric cancer progression.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2017Article
- Onco-GPCR signaling and dysregulated expression of microRNAs in human cancer.Journal of human genetics · 2017Review
- MiR-129-2 functions as a tumor suppressor in glioma cells by targeting HMGB1 and is down-regulated by DNA methylation.Molecular and cellular biochemistry · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs) are a class of small noncoding RNAs, which regulate gene expression in the posttranscriptional level. They are involved in cancer occurrence and development. Different members of the same miRNA family may have different roles. Since the fact that metastasis is the main cause of cancer-related death and miR-129 has three members, in this study, we focused on the migration inhibitory role of miR-129-1-3p in gastric cancer and explored the possible mechanisms. We first compared the expression of three miR-129 family members, miR-129-5p, miR-129-1-3p, and miR-129-2-3p, between gastric carcinoma tissues and surgical margin non-cancer samples by quantitative real-time reverse transcription-polymerase chain reaction (QRT-PCR). Then, we selected miR-129-1-3p for further analysis and transfected its mimic and inhibitor into gastric cancer BGC-823 cells, respectively. Then, we compared the BGC-823 cells' migration capacity by transwell assay. Finally, we predicted the possible targets of miR-129-1-3p and selected one target for further analysis by QRT-PCR and luciferase reporter assay. The results showed that the expression of miR-129-1-3p in gastric carcinoma was significantly lower than that in surgical margin samples. And miR-129-1-3p could inhibit the migration of BGC-823 cells. From the candidates, we selected bradykinin receptor B2 (BDKRB2), which was reported relating to metastasis, as a target for further analysis. QRT-PCR showed that the expression of BDKRB2 was negatively related to miR-129-1-3p. Luciferase reporter assay showed that BDKRB2 was the target of the miR-129-1-3p. In summary, miR-129-1-3p inhibits the BGC-823 cell migration by targeting BDKRB2.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.