ArticleInternational journal of molecular sciences2014
First isolation of new canine parvovirus 2a from Tibetan mastiff and global analysis of the full-length VP2 gene of canine parvoviruses 2 in China.
Article in International journal of molecular sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic literature review and meta-analysis of characterization of canine parvoviruses 2 prevalent in mainland China.Virology journal · 2020Pooled it
- Identification and Characterization of Canine Parvoviruses and Emergence of Canine Bocavirus and Bufavirus from Diarrheic Dogs in Sichuan Province, China.Veterinary sciences · 2026Article
- Genome Sequences of Canine Parvovirus Type 2c Prevalent in Western Mexico.Archives of Razi Institute · 2024Article
- Prevalence and Characteristics of Canine Parvovirus Type 2 in Henan Province, China.Microbiology spectrum · 2022Article
- Exclusive circulation of canine parvovirus type 2c in the Guadalajara metropolitan area in western Mexico: a five-year study.Archives of virology · 2022Article
- Molecular epidemiology of canine parvovirus 2 from 2014, 2019, and 2021 shows CPV2 circulating and CPV2c increasing in Yanbian, China.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2022Article
- Identification of a Novel Ichthyic Parvovirus in Marine Species in Hainan Island, China.Frontiers in microbiology · 2019Article
- Molecular characterization of canine parvovirus variants (CPV-2a, CPV-2b, and CPV-2c) based on theVeterinary world · 2018Article
- Phylodynamic and Genetic Diversity of Canine Parvovirus Type 2c in Taiwan.International journal of molecular sciences · 2017Article
- Identification of a novel canine parvovirus type 2c in Taiwan.Virology journal · 2016Article
- Occurrence of canine parvovirus in dogs from Henan province of China in 2009-2014.BMC veterinary research · 2016Article
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Authors and funding
12 authors.
Funding
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Abstract
Canine parvovirus 2 (CPV-2) was first identified in 1978, and is responsible for classic parvoviral enteritis. Despite the widespread vaccination of domestic carnivores, CPVs have remained important pathogens of domestic and wild carnivores. In this study, we isolated CPV-2 from Tibetan mastiffs and performed a global analysis of the complete VP2 gene sequences of CPV-2 strains in China. Six isolates were typed as new CPV-2a, according to key amino acid positions. On a phylogenetic tree, these six sequences formed a distinct clade. Five isolates occurred on the same branch as KF785794 from China and GQ379049 from Thailand; CPV-LS-ZA1 formed a separate subgroup with FJ435347 from China. One hundred ninety-eight sequences from various parts of China and the six sequences isolated here formed seven distinct clusters, indicating the high diversity of CPVs in China. Of 204 VP2 sequences, 183 (91.04%) encoded the mutation Ser297Ala, regardless of the antigenic type, implying that most Chinese CPV-2 strains contain the VP2 mutation Ser297Ala. However, the biological significance of this change from prototype CPV-2a/2b to new CPV-2a/2b types remains unclear. This study is the first to isolate new CPV-2a from the Tibetan mastiff. Our data show that new CPV-2a/2b variants are now circulating in China.
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