ArticleMetabolic syndrome and related disorders2014
Baseline levels, and changes over time in body mass index and fasting insulin, and their relationship to change in metabolic trait clustering.
Article in Metabolic syndrome and related disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Metabolic phenotypes of obesity: frequency, correlates and change over time in a cohort of postmenopausal women.International journal of obesity (2005) · 2017Trial
- Type-2 diabetes mellitus with or without metabolic syndrome and their associated critical factors: A study from Northern India.Journal of family medicine and primary care · 2024Article
- The Association between Oligomenorrhea, Onset of Menopause and Metabolic Syndrome in Thai Postmenopausal Women.Journal of menopausal medicine · 2018Article
- Observational
- Metabesity and urological cancers.Turkish journal of urology · 2017Review
- Metabolic Syndrome Components are Associated with Increased Prostate Cancer Risk.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Biochemical changes in blood of type 2 diabetes with and without metabolic syndrome and their association with metabolic syndrome components.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2015Article
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundMultiple abnormal metabolic traits are found together or "cluster" within individuals more often than is predicted by chance. The individual and combined role of adiposity and insulin resistance (IR) on metabolic trait clustering is uncertain. We tested the hypothesis that change in trait clustering is a function of both baseline level and change in these measures.
methodsIn 2616 nondiabetic Framingham Offspring Study participants, body mass index (BMI) and fasting insulin were related to a within-person 7-year change in a trait score of 0-4 Adult Treatment Panel III metabolic syndrome traits (hypertension, high triglycerides, low high-density lipoprotein cholesterol, hyperglycemia).
resultsAt baseline assessment, mean trait score was 1.4 traits, and 7-year mean (SEM) change in trait score was +0.25 (0.02) traits, P<0.0001. In models with BMI predictors only, for every quintile difference in baseline BMI, the 7-year trait score increase was 0.14 traits, and for every quintile increase in BMI during 7-year follow-up, the trait score increased by 0.3 traits. Baseline level and change in fasting insulin were similarly related to trait score change. In models adjusted for age-sex-baseline cluster score, 7-year change in trait score was significantly related to both a 1-quintile difference in baseline BMI (0.07 traits) and fasting insulin (0.18 traits), and to both a 1-quintile 7-year increase in BMI (0.21 traits) and fasting insulin (0.18 traits).
conclusionsChange in metabolic trait clustering was significantly associated with baseline levels and changes in both BMI and fasting insulin, highlighting the importance of both obesity and IR in the clustering of metabolic traits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.