ArticlePloS one2014
Polymorphisms of SP110 are associated with both pulmonary and extra-pulmonary tuberculosis among the Vietnamese.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Molecular epidemiology of M. tuberculosis in Ethiopia: A systematic review and meta-analysis.Tuberculosis (Edinburgh, Scotland) · 2019Pooled it
- Certain Polymorphisms in SP110 Gene Confer Susceptibility to Tuberculosis: A Comprehensive Review and Updated Meta-Analysis.Yonsei medical journal · 2017Pooled it
- Consensus Pituitary Atlas, a scalable resource for annotation, novel marker discovery, and analyses in mouse pituitary gland research.Cell reports · 2026Article
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- Polymorphisms in theJournal of immunology research · 2022Article
- Whole genome sequencing identifies novel genetic mutations in patients with eczema herpeticum.Allergy · 2021Article
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- Whole-genome comparative analysis at the lineage/sublineage level discloses relationships betweenPeerJ · 2021Article
- Genetic Variants in Immune Related Genes as Predictors of Responsiveness to BCG Immunotherapy in Metastatic Melanoma Patients.Cancers · 2020Article
- The Speckled Protein (SP) Family: Immunity's Chromatin Readers.Trends in immunology · 2020Review
- Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by IL-1Ra.Nature microbiology · 2019Article
- Harnessing genomic information for livestock improvement.Nature reviews. Genetics · 2019Review
- Functional domains of SP110 that modulate its transcriptional regulatory function and cellular translocation.Journal of biomedical science · 2018Article
- Article
- Sp110 enhances macrophage resistance toOncotarget · 2017Article
- SP110b Controls Host Immunity and Susceptibility to Tuberculosis.American journal of respiratory and critical care medicine · 2017Article
- Determinants of site of tuberculosis disease: An analysis of European surveillance data from 2003 to 2014.PloS one · 2017Article
- SP110 and PMP22 polymorphisms are associated with tuberculosis risk in a Chinese-Tibetan population.Oncotarget · 2016Article
- Molecular characterization of Sp110 gene in pigs.Molecular genetics and genomics : MGG · 2016Article
- Characterization of promoter of the tuberculosis-resistant gene intracellular pathogen resistance 1.Immunologic research · 2016Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTuberculosis (TB) is an infectious disease that remains a major cause of morbidity and mortality worldwide, yet the reasons why only 10% of people infected with Mycobacterium tuberculosis go on to develop clinical disease are poorly understood. Genetically determined variation in the host immune response is one factor influencing the response to M. tuberculosis. SP110 is an interferon-responsive nuclear body protein with critical roles in cell cycling, apoptosis and immunity to infection. However association studies of the gene with clinical TB in different populations have produced conflicting results.
methodsTo examine the importance of the SP110 gene in immunity to TB in the Vietnamese we conducted a case-control genetic association study of 24 SP110 variants, in 663 patients with microbiologically proven TB and 566 unaffected control subjects from three tertiary hospitals in northern Vietnam.
resultsFive SNPs within SP110 were associated with all forms of TB, including four SNPs at the C terminus (rs10208770, rs10498244, rs16826860, rs11678451) under a dominant model and one SNP under a recessive model, rs7601176. Two of these SNPs were associated with pulmonary TB (rs10208770 and rs16826860) and one with extra-pulmonary TB (rs10498244).
conclusionSP110 variants were associated with increased susceptibility to both pulmonary and extra-pulmonary TB in the Vietnamese. Genetic variants in SP110 may influence macrophage signaling responses and apoptosis during M. tuberculosis infection, however further research is required to establish the mechanism by which SP110 influences immunity to tuberculosis infection.
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