ArticleMolecules (Basel, Switzerland)2014
Synthesis of riboflavines, quinoxalinones and benzodiazepines through chemoselective flow based hydrogenations.
Article in Molecules (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Hepatoprotective Principles and Other Chemical Constituents from the Mycelium of Phellinus linteus.Molecules (Basel, Switzerland) · 2018Article
- The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry.Beilstein journal of organic chemistry · 2015Review
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Authors and funding
6 authors.
Funding
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Abstract
Robust chemical routes towards valuable bioactive entities such as riboflavines, quinoxalinones and benzodiazepines are described. These make use of modern flow hydrogenation protocols enabling the chemoselective reduction of nitro group containing building blocks in order to rapidly generate the desired amine intermediates in situ. In order to exploit the benefits of continuous processing the individual steps were transformed into a telescoped flow process delivering selected benzodiazepine products on scales of 50 mmol and 120 mmol respectively.
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Registered trials
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