Evidence map›Paper›PMID 25006678›Full record

Trial reportPloS one2014

Ergocalciferol and microcirculatory function in chronic kidney disease and concomitant vitamin d deficiency: an exploratory, double blind, randomised controlled trial.

Gavin Dreyer, Arthur T Tucker, Steven M Harwood, Rupert M Pearse, Martin J Raftery, Muhammad M Yaqoob

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00882401 (The Effect of Vitamin D on the Microcirculation of Patients With Chronic Kidney Disease), which is not on this map. Cited by 30 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 6 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00882401 phase4completednot on this map

The Effect of Vitamin D on the Microcirculation of Patients With Chronic Kidney Disease (CKD) and Vitamin D Deficiency

TypeinterventionalSponsorBarts & The London NHS TrustRan2009 to 2010Enrolled64ConditionsChronic Kidney Disease, Vitamin D DeficiencyArmsErgocalciferol (Vitamin D), Placebo
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 6 syntheses or guidelines pooled it, 77 citations in OpenAlex.

  1. Pooled it
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  10. A Randomized Trial of Vitamin D Supplementation on Vascular Function in CKD.Journal of the American Society of Nephrology : JASN · 2017
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  16. The role of nutritional vitamin D in chronic kidney disease-mineral and bone disorder in children and adults with chronic kidney disease, on dialysis, and after kidney transplantation-a European consensus statement.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Gavin DreyerDepartment of Renal Medicine, Barts Health NHS Trust, London, United Kingdom; Department of Translational Medicine and Therapeutics, Queen Mary University of London, London, United Kingdom.
Arthur T TuckerErnest Cooke Microvascular Unit, Barts Health NHS Trust, London, United Kingdom.
Steven M HarwoodDepartment of Translational Medicine and Therapeutics, Queen Mary University of London, London, United Kingdom.
Rupert M PearseDepartment of Critical Care Medicine, Barts Health NHS Trust, London, United Kingdom.
Martin J RafteryDepartment of Renal Medicine, Barts Health NHS Trust, London, United Kingdom.
Muhammad M YaqoobDepartment of Renal Medicine, Barts Health NHS Trust, London, United Kingdom; Department of Translational Medicine and Therapeutics, Queen Mary University of London, London, United Kingdom.
Barts Health NHS Trust · GBQueen Mary University of London · GB

Funding

Department of Health CS/08/08/17Department of Health RP_2014-04-022
6 · The paper itself

Abstract

BACKGROUND AND

objectivesVitamin D deficiency and endothelial dysfunction are non-traditional risk factors for cardiovascular events in chronic kidney disease. Previous studies in chronic kidney disease have failed to demonstrate a beneficial effect of vitamin D on arterial stiffness, left ventricular mass and inflammation but none have assessed the effect of vitamin D on microcirculatory endothelial function. STUDY

designWe conducted a randomised controlled trial of 38 patients with non diabetic chronic kidney disease stage 3-4 and concomitant vitamin D deficiency (<16 ng/dl) who received oral ergocalciferol (50,000 IU weekly for one month followed by 50,000 IU monthly) or placebo over 6 months. The primary outcome was change in microcirculatory function measured by laser Doppler flowmetry after iontophoresis of acetylcholine. Secondary endpoints were tissue advanced glycation end products, sublingual functional capillary density and flow index as well as macrovascular parameters. Parallel in vitro experiments were conducted to determine the effect of ergocalciferol on cultured human endothelial cells.

resultsTwenty patients received ergocalciferol and 18 patients received placebo. After 6 months, there was a significant improvement in the ergocalciferol group in both endothelium dependent microcirculatory vasodilatation after iontophoresis of acetylcholine (p = 0.03) and a reduction in tissue advanced glycation end products (p = 0.03). There were no changes in sublingual microcirculatory parameters. Pulse pressure (p = 0.01) but not aortic pulse wave velocity was reduced. There were no significant changes in bone mineral parameters, blood pressure or left ventricular mass index suggesting that ergocalciferol improved endothelial function independently of these parameters. In parallel experiments, expression of endothelial nitric oxide synthase and activity were increased in human endothelial cells in a dose dependent manner.

conclusionsErgocalciferol improved microcirculatory endothelial function in patients with chronic kidney disease and concomitant vitamin D deficiency. This process may be mediated through enhanced expression and activity of endothelial nitric oxide synthase.

trial registrationClinical trials.gov NCT00882401.

Indexed as

Administration, OralAdultComorbidityDrug Administration ScheduleErgocalciferolsFemaleGlycation End Products, AdvancedHumansKidneyMaleMicrocirculationMiddle AgedRenal Insufficiency, ChronicTreatment OutcomeVitamin D DeficiencyVitaminsErgocalciferolsGlycation End Products, AdvancedVitamins

Identifiers

PMID25006678
PMCPMC4090117
OpenAlexW1966506433

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.