ReviewJournal of bone metabolism2014
Genetics of ossification of the posterior longitudinal ligament of the spine: a mini review.
Review in Journal of bone metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Potential Link between Ossification of Nuchal Ligament and the Risk of Cervical Ossification of Posterior Longitudinal Ligament: Evidence and Clinical Implication from a Meta-Analysis of 8429 Participants.Orthopaedic surgery · 2021Pooled it
- Involvement of reduced ENPP1 function in the pathogenesis of ossification of the posterior longitudinal ligament.JBMR plus · 2026Article
- Baseline characteristics, perioperative complications, and 1-year outcomes in cervical OPLL versus cervical spondylotic myelopathy: a multicenter retrospective cohort study.North American Spine Society journal · 2026Article
- Screening and Predictive Value of Thoracic Ossification Observed on Lateral Radiography for Myelopathy.Yonsei medical journal · 2026Article
- Angiogenesis in ossification of the posterior longitudinal ligament: progress from mechanism to targeted intervention.Frontiers in cell and developmental biology · 2026Review
- Proteomic analysis and effects on osteogenic differentiation of exosomes from patients with ossification of the spinal ligament.JBMR plus · 2025Article
- The imaging of cervical spondylotic myeloradiculopathy.Skeletal radiology · 2023Review
- Correlation Between the Severity of Multifidus Fatty Degeneration and the Size of Ossification of Posterior Longitudinal Ligament at Each Spinal Level.Neurospine · 2023Article
- A novel CCDC91 isoform associated with ossification of the posterior longitudinal ligament of the spine works as a non-coding RNA to regulate osteogenic genes.American journal of human genetics · 2023Article
- Burosumab Treatment for Autosomal Recessive Hypophosphatemic Rickets Type 1 (ARHR1).The Journal of clinical endocrinology and metabolism · 2022Article
- Small extracellular vesicle-mediated miR-320e transmission promotes osteogenesis in OPLL by targeting TAK1.Nature communications · 2022Article
- The COL6A1 rs201153092 single nucleotide polymorphism, associates with thoracic ossification of the posterior longitudinal ligament.Molecular medicine reports · 2020Article
- A new single nucleotide polymorphism affects the predisposition to thoracic ossification of the posterior longitudinal ligament.Journal of orthopaedic surgery and research · 2019Article
- IL17RC affects the predisposition to thoracic ossification of the posterior longitudinal ligament.Journal of orthopaedic surgery and research · 2019Article
- Potential role of the IL17RC gene in the thoracic ossification of the posterior longitudinal ligament.International journal of molecular medicine · 2019Article
- Ossification of the posterior longitudinal ligament in the cervical spine: a review.International orthopaedics · 2019Review
- Calcification of the intervertebral disc and ossification of posterior longitudinal ligament in children.BMC musculoskeletal disorders · 2018Review
- Association of IL17RC and COL6A1 genetic polymorphisms with susceptibility to ossification of the thoracic posterior longitudinal ligament in Chinese patients.Journal of orthopaedic surgery and research · 2018Article
- Targeted next-generation sequencing reveals multiple deleterious variants in OPLL-associated genes.Scientific reports · 2016Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ossification of the posterior longitudinal ligament of the spine (OPLL) is a common disease in aging populations and sometimes results in serious neurological problems due to compression of the spinal cord and nerve roots. OPLL is a multi-factorial (polygenic) disease controlled by genetic and environmental factors. Studies searching for the genetic component of OPLL, using linkage and association analyses, are in progress and several susceptibility genes have been reported. This paper reviews the recent progress in the genetic study of OPLL and comments on its future task.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.