ArticlePulmonary circulation2014
A unique pulmonary microvascular endothelial cell niche revealed by Weibel-Palade bodies and Griffonia simplicifolia.
Article in Pulmonary circulation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Equip your vehicle for the right terrain: Using features of local pathology to guide engineering of targeted drug delivery systems.Journal of controlled release : official journal of the Controlled Release Society · 2026Review
- Endothelial Heterogeneity in Pulmonary Hypertension.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- von Willebrand Factor: An Unhealthy Bond between Lung Endothelium and Pulmonary Fibrosis.American journal of respiratory cell and molecular biology · 2025Article
- Dynamic behavior and lineage plasticity of the pulmonary venous endothelium.Nature cardiovascular research · 2024Article
- Lung endothelium, tau, and amyloids in health and disease.Physiological reviews · 2024Review
- Transcriptional profiles of pulmonary artery endothelial cells in pulmonary hypertension.Scientific reports · 2023Article
- Alveolar Vascular Remodeling in Nonspecific Interstitial Pneumonia: Replacement of Normal Lung Capillaries withAmerican journal of respiratory and critical care medicine · 2023Article
- Endothelial cell activation, Weibel-Palade body secretion, and enhanced angiogenesis in severe COVID-19.Research and practice in thrombosis and haemostasis · 2023Article
- Carbonic anhydrase IX proteoglycan-like and intracellular domains mediate pulmonary microvascular endothelial cell repair and angiogenesis.American journal of physiology. Lung cellular and molecular physiology · 2022Article
- Sourcing cells forFrontiers in medical technology · 2022Review
- Endothelial metabolism in pulmonary vascular homeostasis and acute respiratory distress syndrome.American journal of physiology. Lung cellular and molecular physiology · 2021Review
- 2-Chlorofatty Aldehyde Elicits Endothelial Cell Activation.Frontiers in physiology · 2020Article
- Cumulative effects of neonatal hyperoxia on murine alveolar structure and function.Pediatric pulmonology · 2017Article
- Method for the Culture of Mouse Pulmonary Microvascular Endothelial Cells.Scientific pages of pulmonology · 2017Article
- N-Ethylmaleimide Sensitive Factor (NSF) Inhibition Prevents Vascular Instability following Gram-Positive Pulmonary Challenge.PloS one · 2016Article
- The isolation and culture of endothelial colony-forming cells from human and rat lungs.Nature protocols · 2015Article
- Permeability and calcium signaling in lung endothelium: unpack the box….Pulmonary circulationArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Pulmonary endothelium displays considerable heterogeneity along the vascular axis, from arteries to capillaries to veins. Griffonia simplicifolia is a lectin that recognizes pulmonary microvascular endothelium with preference over extra-alveolar endothelium in both arteries and veins, yet the precise vascular location where this phenotypic shift occurs is poorly resolved. We gelatin-filled the circulation and agarose-loaded the airways and then labeled the lung with Griffonia lectin to enable visualization of the endothelial transition zone. Endothelium in vessels with internal diameters less than 38 μm were uniformly Griffonia positive, whereas vessels with internal diameters greater than 60 μm were always Griffonia negative. Two populations of endothelium were identified in vessels ranging from 38 to 60 μm in diameter, including some that were positive and others that were negative for binding to G. simplicifolia. To better resolve this endothelial transition zone, we performed morphology studies to measure the distribution of Weibel-Palade bodies (WPbs), since WPbs are present in conduit vessel endothelium and absent in capillary endothelium. WPbs were found in endothelium with vascular dimensions as small as 18 μm in diameter but were not found in capillaries. Thus, we identify with precision that the endothelial phenotype transition from a cell that does not interact with Griffonia lectin to one that does occurs in blood vessels with internal diameters of approximately 38 μm, and we reveal an unappreciated vascular zone, between 18 and 38 μm in diameter, where endothelium both is Griffonia positive and possesses WPbs.
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