ArticleThe American journal of case reports2014
Strabismus and diplopia in a patient with acute myeloid leukemia.
Article in The American journal of case reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Ocular Manifestations in Hematological Disorders.Cureus · 2022Article
- Early Ophthalmological Manifestations of Acute Myeloid Leukemia: Current Perspectives.Clinical ophthalmology (Auckland, N.Z.) · 2022Review
- A narrative review of central nervous system involvement in acute leukemias.Annals of translational medicine · 2021Review
- Acute Myeloid Leukemia Relapse Presenting as Complete Monocular Vision Loss due to Optic Nerve Involvement.Case reports in hematology · 2016Article
- Pseudo-Guillain-Barré syndrome masking acute myeloid leukemia relapse: Brief report and review.Leukemia research reports · 2015Article
- A 51-year-old woman with binocular diplopia and unilateral ptosis.Digital journal of ophthalmology : DJOArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
patientMale, 64 FINAL DIAGNOSIS: Acute myeloid leukemia (AML) Symptoms: - MEDICATION: - Clinical Procedure: - Specialty: -
objectiveUnusual clinical course.
backgroundCentral nervous system (CNS) involvement is a sporadic presenting finding in patients with acute myeloid leukemia (AML) both at diagnosis and at relapse. Moreover patients with CNS localization are often asymptomatic, while sometimes show meningeal signs and symptoms or, extremely rarely, signs of cranial nerve impairment. CASE REPORT: Here we report on a patient with refractory AML who suddenly developed strabismus and diplopia. Both neurological and ophtalmologic examinations were suggestive of a bilateral VI cranial nerve palsy. Noteworthy, both a cranial CT and MRI were substantially normal, while a rachicentesis was performed and cerebrospinal fluid examination was clearly suggestive of a meningeal involvement by AML.
conclusionsThis is to our knowledge the first reported case in which the clinical picture of meningeal localization in an AML patient was dominated by an isolated abducens cranial nerve impairment. Moreover it highlights as unexplained strabismus and diplopia can be considered as a potential sign of CNS involvement, even if conventional imaging is negative.
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