Evidence map›Paper›PMID 25006344›Full record

ArticleClinical practice and epidemiology in mental health : CP & EMH2014

Quality of life, cortisol blood levels and exercise in older adults: results of a randomized controlled trial.

Gioia Mura, Giulia Cossu, Gian M Migliaccio, Claudio Atzori, Antonio E Nardi, Sergio Machado, Mauro G Carta

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Clinical practice and epidemiology in mental health : CP & EMH, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03858114 (Active Ageing and Health), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03858114 nacompletednot on this mapstarted 2019, after this paper: background citation

Active Ageing and Health

TypeinterventionalSponsorUniversity of CagliariRan2019 to 2020Enrolled140ConditionsAging, Chronic Disease, Cognitive Decline, Quality of LifeArmsMild-to-moderate physical activity, Cultural group program
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. "Shedding Light on Light": A Review on the Effects on Mental Health of Exposure to Optical Radiation.International journal of environmental research and public health · 2021
    Review
  6. Article
  7. Article
  8. Article
  9. The Physical Body Experiences Questionnaire Simplified for Active Aging (PBE-QAG).Clinical practice and epidemiology in mental health : CP & EMH · 2018
    Article
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Gioia MuraDepartment of Public Health, Clinical and Molecular Medicine, University of Cagliari, Italy.
Giulia CossuDepartment of Public Health, Clinical and Molecular Medicine, University of Cagliari, Italy.
Gian M MigliaccioCONI Italian Olympic Committee, Sardinia, Italy.
Claudio AtzoriCMT Medical Analysis Laboratory, Cagliari, Italy.
Antonio E NardiPanic and Respiration Laboratory, Institute of Psychiatry of Federal University of Rio de Janeiro (IPUB/UFRJ), Brazil; National Institute of Translational Medicine (INCT-TM).
Sergio MachadoPanic and Respiration Laboratory, Institute of Psychiatry of Federal University of Rio de Janeiro (IPUB/UFRJ), Brazil; National Institute of Translational Medicine (INCT-TM) ; Physical Activity Neuroscience Laboratory (LABNAF), Physical Activity Sciences Postgraduate Program of Salgado de Oliveira University (PPGCAF/UNIVERSO), Niterói, Brazil.
Mauro G CartaDepartment of Public Health, Clinical and Molecular Medicine, University of Cagliari, Italy.
University of Cagliari · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCortisol plays a central role in the stress response; while high stress can determine physical and psychological impairment, moderate stress, with a mild increase in cortisol level, may have a positive effect on coping and physical performance. This trial attempted to determine whether cortisol levels were associated with Quality of Life (QoL) in a sample of elderly subjects undertaking an exercise program.

methods42 subjects aged ≥65 years were randomlyassigned in a 1:1 fashion either to a vigorous physical activity (VAG: N=21) or to a postural gimnastic group (PGG: N=21). Differences between the two groups in QoL (on SF-12), and blood cortisol levels were assessed by ANOVA at different times.

resultsIn both the VAG and PGG, cortisol levels rose at the end of the trial, with statistically significant differences as compared to the baseline. QoL at the end of the trial was higher than in the national normative sample. Cortisol and QoL in both groups decreased slightly 12 weeks after the end of the trial (T2); however, only in the VAG did the difference from the initial level remain statistically significant. At T1 and T2, subjects with higher SF-12 scores were found in subsamples in both groups with cortisol levels moderately increased (between 200 and 300 mg/ml).

conclusionIn a sample of elderly subjects undergoing two different kinds of exercise, a better perception of Quality of Life was associated with a moderate, non-pathological increase in cortisol. The results need to be confirmed by trials on larger samples.

Indexed as

Cortisolelderlyexercisequality of life.

Identifiers

PMID25006344
PMCPMC4085586
OpenAlexW2081753037

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.