ReviewJournal of the National Cancer Institute2014
Recommended patient-reported core set of symptoms and quality-of-life domains to measure in ovarian cancer treatment trials.
Open access · bronzeAbstract readConsensus Development Conference, NIHReview
In one paragraph
Review in Journal of the National Cancer Institute, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 5 pooled it
3.1field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 5 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Angiogenesis inhibitors for the treatment of epithelial ovarian cancer.The Cochrane database of systematic reviews · 2023Pooled it
- Development of a core outcome set for myelodysplastic syndromes - a Delphi study from the EUMDS Registry Group.British journal of haematology · 2020Pooled it
- A Systematic Review of Health-Related Quality of Life Reporting in Ovarian Cancer Phase III Clinical Trials: Room to Improve.The oncologist · 2018Pooled it
- A systematic review of ovarian cancer and fear of recurrence.Palliative & supportive care · 2015Pooled it
- Recommended patient-reported core set of symptoms to measure in adult cancer treatment trials.Journal of the National Cancer Institute · 2014Pooled it
- Overall survival and patient-reported outcome results from the placebo-controlled randomized phase III IMagyn050/GOG 3015/ENGOT-OV39 trial of atezolizumab for newly diagnosed stage III/IV ovarian cancer.Gynecologic oncology · 2023Trial
- Quality of life with cediranib in relapsed ovarian cancer: The ICON6 phase 3 randomized clinical trial.Cancer · 2017Trial
- Exploring potential methylation markers for ovarian cancer from cervical scraping samples.Human genomics · 2025Article
- Radiotherapy toxicities: mechanisms, management, and future directions.Lancet (London, England) · 2025Review
- Non-coding RNAs as key regulators of epithelial-mesenchymal transition in breast cancer.Frontiers in cell and developmental biology · 2025Review
- Integrating 4 methods to evaluate physical function in patients with cancer (In4M): protocol for a prospective cohort study.BMJ open · 2024Article
- A multi-method approach to selecting PRO-CTCAE symptoms for patient-reported outcome in women with endometrial or ovarian cancer undergoing chemotherapy.Journal of patient-reported outcomes · 2023Article
- Developing and Field Testing BOLSTER: A Nurse-Led Care Management Intervention to Support Patients and Caregivers following Hospitalization for Gynecologic Cancer-Associated Peritoneal Carcinomatosis.Journal of palliative medicine · 2022Article
- Defining a Standard Set of Patient-Reported Outcomes for Patients With Advanced Ovarian Cancer.Frontiers in oncology · 2022Article
- Patient-reported outcome changes at the end of life in recurrent platinum-resistant ovarian cancer: An NRG oncology/GOG study.Gynecologic oncology · 2021Article
- Measuring Quality of Life in Ovarian Cancer Clinical Trials-Can We Improve Objectivity and Cross Trial Comparisons?Cancers · 2020Review
- Core outcome sets in cancer and their approaches to identifying and selecting patient-reported outcome measures: a systematic review.Journal of patient-reported outcomes · 2020Review
- Testing Symptom Severity Thresholds and Potential Alerts for Clinical Intervention in Patients With Cancer Undergoing Chemotherapy.JCO oncology practice · 2020Article
- Development of a Core Set of Patient-Reported Outcomes for Population-Based Cancer Survivorship Research: Protocol for an Australian Consensus Study.JMIR research protocols · 2020Article
- A practical guide to understanding, using and including patient reported outcomes in clinical trials in ovarian cancer.Journal of gynecologic oncology · 2018Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Kristine A DonovanAffiliations of authors: Supportive Care Medicine Department, Health Outcomes and Behavior Program, Moffitt Cancer Center, Tampa, FL (KAD); Acute and Tertiary Care Department, University of Pittsburgh School of Nursing, Pittsburgh, PA (HSD); Department of Medical Social Sciences and the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL (DC); Center for Patient Partnership, University of Wisconsin Law School, Madison, WI (MEG); Department of Medicine, Massachusetts General Hospital, Boston, MA (RTP); Department of Reproductive Medicine, Division of Gynecologic Oncology, University of California-San Diego, San Diego, CA (SCP); Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Summa Akron City Hospital, Akron, OH (VEvG); School of Nursing, Emory University, Atlanta, GA (DWB); Department of Health Policy and Management, University of North Carolina, Chapel Hill, NC (BBR); Department of Medicine, University of California, Irvine, Irvine, CA (LW).
Heidi S DonovanAffiliations of authors: Supportive Care Medicine Department, Health Outcomes and Behavior Program, Moffitt Cancer Center, Tampa, FL (KAD); Acute and Tertiary Care Department, University of Pittsburgh School of Nursing, Pittsburgh, PA (HSD); Department of Medical Social Sciences and the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL (DC); Center for Patient Partnership, University of Wisconsin Law School, Madison, WI (MEG); Department of Medicine, Massachusetts General Hospital, Boston, MA (RTP); Department of Reproductive Medicine, Division of Gynecologic Oncology, University of California-San Diego, San Diego, CA (SCP); Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Summa Akron City Hospital, Akron, OH (VEvG); School of Nursing, Emory University, Atlanta, GA (DWB); Department of Health Policy and Management, University of North Carolina, Chapel Hill, NC (BBR); Department of Medicine, University of California, Irvine, Irvine, CA (LW).
David CellaAffiliations of authors: Supportive Care Medicine Department, Health Outcomes and Behavior Program, Moffitt Cancer Center, Tampa, FL (KAD); Acute and Tertiary Care Department, University of Pittsburgh School of Nursing, Pittsburgh, PA (HSD); Department of Medical Social Sciences and the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL (DC); Center for Patient Partnership, University of Wisconsin Law School, Madison, WI (MEG); Department of Medicine, Massachusetts General Hospital, Boston, MA (RTP); Department of Reproductive Medicine, Division of Gynecologic Oncology, University of California-San Diego, San Diego, CA (SCP); Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Summa Akron City Hospital, Akron, OH (VEvG); School of Nursing, Emory University, Atlanta, GA (DWB); Department of Health Policy and Management, University of North Carolina, Chapel Hill, NC (BBR); Department of Medicine, University of California, Irvine, Irvine, CA (LW).
Martha E GainesAffiliations of authors: Supportive Care Medicine Department, Health Outcomes and Behavior Program, Moffitt Cancer Center, Tampa, FL (KAD); Acute and Tertiary Care Department, University of Pittsburgh School of Nursing, Pittsburgh, PA (HSD); Department of Medical Social Sciences and the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL (DC); Center for Patient Partnership, University of Wisconsin Law School, Madison, WI (MEG); Department of Medicine, Massachusetts General Hospital, Boston, MA (RTP); Department of Reproductive Medicine, Division of Gynecologic Oncology, University of California-San Diego, San Diego, CA (SCP); Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Summa Akron City Hospital, Akron, OH (VEvG); School of Nursing, Emory University, Atlanta, GA (DWB); Department of Health Policy and Management, University of North Carolina, Chapel Hill, NC (BBR); Department of Medicine, University of California, Irvine, Irvine, CA (LW).
Richard T PensonAffiliations of authors: Supportive Care Medicine Department, Health Outcomes and Behavior Program, Moffitt Cancer Center, Tampa, FL (KAD); Acute and Tertiary Care Department, University of Pittsburgh School of Nursing, Pittsburgh, PA (HSD); Department of Medical Social Sciences and the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL (DC); Center for Patient Partnership, University of Wisconsin Law School, Madison, WI (MEG); Department of Medicine, Massachusetts General Hospital, Boston, MA (RTP); Department of Reproductive Medicine, Division of Gynecologic Oncology, University of California-San Diego, San Diego, CA (SCP); Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Summa Akron City Hospital, Akron, OH (VEvG); School of Nursing, Emory University, Atlanta, GA (DWB); Department of Health Policy and Management, University of North Carolina, Chapel Hill, NC (BBR); Department of Medicine, University of California, Irvine, Irvine, CA (LW).
Steven C PlaxeAffiliations of authors: Supportive Care Medicine Department, Health Outcomes and Behavior Program, Moffitt Cancer Center, Tampa, FL (KAD); Acute and Tertiary Care Department, University of Pittsburgh School of Nursing, Pittsburgh, PA (HSD); Department of Medical Social Sciences and the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL (DC); Center for Patient Partnership, University of Wisconsin Law School, Madison, WI (MEG); Department of Medicine, Massachusetts General Hospital, Boston, MA (RTP); Department of Reproductive Medicine, Division of Gynecologic Oncology, University of California-San Diego, San Diego, CA (SCP); Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Summa Akron City Hospital, Akron, OH (VEvG); School of Nursing, Emory University, Atlanta, GA (DWB); Department of Health Policy and Management, University of North Carolina, Chapel Hill, NC (BBR); Department of Medicine, University of California, Irvine, Irvine, CA (LW).
Vivian E von GruenigenAffiliations of authors: Supportive Care Medicine Department, Health Outcomes and Behavior Program, Moffitt Cancer Center, Tampa, FL (KAD); Acute and Tertiary Care Department, University of Pittsburgh School of Nursing, Pittsburgh, PA (HSD); Department of Medical Social Sciences and the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL (DC); Center for Patient Partnership, University of Wisconsin Law School, Madison, WI (MEG); Department of Medicine, Massachusetts General Hospital, Boston, MA (RTP); Department of Reproductive Medicine, Division of Gynecologic Oncology, University of California-San Diego, San Diego, CA (SCP); Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Summa Akron City Hospital, Akron, OH (VEvG); School of Nursing, Emory University, Atlanta, GA (DWB); Department of Health Policy and Management, University of North Carolina, Chapel Hill, NC (BBR); Department of Medicine, University of California, Irvine, Irvine, CA (LW).
Deborah Watkins BrunerAffiliations of authors: Supportive Care Medicine Department, Health Outcomes and Behavior Program, Moffitt Cancer Center, Tampa, FL (KAD); Acute and Tertiary Care Department, University of Pittsburgh School of Nursing, Pittsburgh, PA (HSD); Department of Medical Social Sciences and the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL (DC); Center for Patient Partnership, University of Wisconsin Law School, Madison, WI (MEG); Department of Medicine, Massachusetts General Hospital, Boston, MA (RTP); Department of Reproductive Medicine, Division of Gynecologic Oncology, University of California-San Diego, San Diego, CA (SCP); Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Summa Akron City Hospital, Akron, OH (VEvG); School of Nursing, Emory University, Atlanta, GA (DWB); Department of Health Policy and Management, University of North Carolina, Chapel Hill, NC (BBR); Department of Medicine, University of California, Irvine, Irvine, CA (LW).
Bryce B ReeveAffiliations of authors: Supportive Care Medicine Department, Health Outcomes and Behavior Program, Moffitt Cancer Center, Tampa, FL (KAD); Acute and Tertiary Care Department, University of Pittsburgh School of Nursing, Pittsburgh, PA (HSD); Department of Medical Social Sciences and the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL (DC); Center for Patient Partnership, University of Wisconsin Law School, Madison, WI (MEG); Department of Medicine, Massachusetts General Hospital, Boston, MA (RTP); Department of Reproductive Medicine, Division of Gynecologic Oncology, University of California-San Diego, San Diego, CA (SCP); Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Summa Akron City Hospital, Akron, OH (VEvG); School of Nursing, Emory University, Atlanta, GA (DWB); Department of Health Policy and Management, University of North Carolina, Chapel Hill, NC (BBR); Department of Medicine, University of California, Irvine, Irvine, CA (LW).
Lari WenzelAffiliations of authors: Supportive Care Medicine Department, Health Outcomes and Behavior Program, Moffitt Cancer Center, Tampa, FL (KAD); Acute and Tertiary Care Department, University of Pittsburgh School of Nursing, Pittsburgh, PA (HSD); Department of Medical Social Sciences and the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL (DC); Center for Patient Partnership, University of Wisconsin Law School, Madison, WI (MEG); Department of Medicine, Massachusetts General Hospital, Boston, MA (RTP); Department of Reproductive Medicine, Division of Gynecologic Oncology, University of California-San Diego, San Diego, CA (SCP); Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Summa Akron City Hospital, Akron, OH (VEvG); School of Nursing, Emory University, Atlanta, GA (DWB); Department of Health Policy and Management, University of North Carolina, Chapel Hill, NC (BBR); Department of Medicine, University of California, Irvine, Irvine, CA (LW). lwenzel@uci.edu.
Robert H. Lurie Comprehensive Cancer Center of Northwestern UniversityUniversity of Pittsburgh · USUniversity of California, Irvine · USUniversity of South Florida · US
Funding
Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5MUniv.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christine Hui · 1994 to 2026
$57.9MNCI NIH HHS P30 CA016086NCI NIH HHS P30 CA062203
Abstract
There is no consensus as to what symptoms or quality-of-life (QOL) domains should be measured as patient-reported outcomes (PROs) in ovarian cancer clinical trials. A panel of experts convened by the National Cancer Institute reviewed studies published between January 2000 and August 2011. The results were included in and combined with an expert consensus-building process to identify the most salient PROs for ovarian cancer clinical trials. We identified a set of PROs specific to ovarian cancer: abdominal pain, bloating, cramping, fear of recurrence/disease progression, indigestion, sexual dysfunction, vomiting, weight gain, and weight loss. Additional PROs identified in parallel with a group charged with identifying the most important PROs across cancer types were anorexia, cognitive problems, constipation, diarrhea, dyspnea, fatigue, nausea, neuropathy, pain, and insomnia. Physical and emotional domains were considered to be the most salient domains of QOL. Findings of the review and consensus process provide good support for use of these ovarian cancer-specific PROs in ovarian cancer clinical trials.
Indexed as
Quality of LifeSelf ReportAnorexiaAntineoplastic AgentsClinical Trials as TopicConstipationDiarrheaFatigueFemaleHealth StatusHumansNational Cancer Institute (U.S.)NauseaOvarian NeoplasmsSurveys and QuestionnairesTreatment OutcomeAntineoplastic Agents
Identifiers
What OpenQuestion holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.