ArticleMedical oncology (Northwood, London, England)2014
N-Acetyltransferase 2 (NAT2) gene polymorphism and exposure to smoking in lung cancer of Chinese males.
Article in Medical oncology (Northwood, London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Pooled it
- CHL1 gene polymorphisms increase lung cancer susceptibility.Oncotarget · 2018Article
- Associations of polymorphisms in NAT2 gene with risk and metastasis of osteosarcoma in young Chinese population.OncoTargets and therapy · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
N-Acetyltransferase 2 (NAT2) is a polymorphic gene encoding the enzyme that metabolizes arylamine and hydrazine moieties. The NAT2 rs1799930 (G590A) may change drug-induced toxicity and affect cancer susceptibility. To investigate the association between NAT2 rs1799930 polymorphism and susceptibility to lung cancer, we performed a hospital-based case-control study, including 259 lung squamous carcinoma patients and 375 cancer-free hospital controls who were matched by age. A total of 10 ml of venous blood from each patient was collected for the genotype testing. NAT2 rs1799930 polymorphism was analyzed by TaqMan allelic discrimination. Our results showed the evidence by the stratified analysis that smokers with dominant genetic model and A allele in NAT2 rs1799930 decreased risk of lung squamous carcinoma with adjusted OR of 0.64 (95 % CI 0.42-0.96, P = 0.032) and 0.74 (95 % CI 0.54-1.00, P = 0.049), respectively. The significantly increased risk of lung squamous carcinoma was observed in those whose pack-years ≥30 or smoking-index ≥400 with adjusted OR of 3.62 (95 % CI 2.49-5.26, P < 0.001) and 4.29 (95 % CI 2.90-6.36, P < 0.001), respectively. In conclusion, NAT2 rs1799930 polymorphism is an important factor of lung squamous carcinoma resistance in Chinese smoking males. People who smoked heavily had a significantly increased risk of lung cancer.
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