ArticleBMC genomics2014
Identification of cucurbitacins and assembly of a draft genome for Aquilaria agallocha.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Cucurbitacins in Plant-Insect Interactions: Biosynthesis, Regulation, Ecological Functions, and Prospects for Crop Protection.Plants (Basel, Switzerland) · 2026Review
- De novo transcriptome assembly and analysis during agarwood induction in Gyrinops versteegii Gilg. seedling.Scientific reports · 2025Article
- Towards sustainable agarwood production: integrating microbial interactions, anatomical changes, and metabolite biosynthesis.Journal of industrial microbiology & biotechnology · 2024Review
- Article
- Review
- Genome-wide analysis of respiratory burst oxidase homolog (Frontiers in plant science · 2023Article
- Cucurbitacins as potential anticancer agents: new insights on molecular mechanisms.Journal of translational medicine · 2022Review
- Genome-wide detection and classification of terpene synthase genes inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2021Article
- Comparison of eight complete chloroplast genomes of the endangered Aquilaria tree species (Thymelaeaceae) and their phylogenetic relationships.Scientific reports · 2020Article
- Chromosomal-level reference genome of the incense tree Aquilaria sinensis.Molecular ecology resources · 2020Article
- Shelf-life in cucurbitacin-containing phytonematicides: Non-conformity to Arrhenius model.PloS one · 2020Article
- Time-based LC-MS/MS analysis provides insights into early responses to mechanical wounding, a major trigger to agarwood formation inRSC advances · 2019Article
- Genome Size, Molecular Phylogeny, and Evolutionary History of the Tribe Aquilarieae (Thymelaeaceae), the Natural Source of Agarwood.Frontiers in plant science · 2018Article
- Assembly: a resource for assembled genomes at NCBI.Nucleic acids research · 2016Article
- The effect of red light and far-red light conditions on secondary metabolism in agarwood.BMC plant biology · 2015Article
- A draft genome of field pennycress (Thlaspi arvense) provides tools for the domestication of a new winter biofuel crop.DNA research : an international journal for rapid publication of reports on genes and genomes · 2015Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAgarwood is derived from Aquilaria trees, the trade of which has come under strict control with a listing in Appendix II of the Convention on International Trade in Endangered Species of Wild Fauna and Flora. Many secondary metabolites of agarwood are known to have medicinal value to humans, including compounds that have been shown to elicit sedative effects and exhibit anti-cancer properties. However, little is known about the genome, transcriptome, and the biosynthetic pathways responsible for producing such secondary metabolites in agarwood.
resultsIn this study, we present a draft genome and a putative pathway for cucurbitacin E and I, compounds with known medicinal value, from in vitro Aquilaria agallocha agarwood. DNA and RNA data are utilized to annotate many genes and protein functions in the draft genome. The expression changes for cucurbitacin E and I are shown to be consistent with known responses of A. agallocha to biotic stress and a set of homologous genes in Arabidopsis thaliana related to cucurbitacin bio-synthesis is presented and validated through qRT-PCR.
conclusionsThis study is the first attempt to identify cucurbitacin E and I from in vitro agarwood and the first draft genome for any species of Aquilaria. The results of this study will aid in future investigations of secondary metabolite pathways in Aquilaria and other non-model medicinal plants.
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