ArticleBMC complementary and alternative medicine2014
Genetic loci associated with changes in lipid levels leading to constitution-based discrepancy in Koreans.
Article in BMC complementary and alternative medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- The discriminative role of angiopoietin-like protein-3 for metabolic syndrome in polycystic ovary syndrome.Revista da Associacao Medica Brasileira (1992) · 2026Article
- Evaluation of rs1748195 ANGPTL3 gene polymorphism in patients with angiographic coronary artery disease compared to healthy individuals.Molecular genetics & genomic medicine · 2023Article
- Relationship between Low Vegetable Consumption, Increased High-Sensitive C-Reactive Protein Level, and Cardiometabolic Risk in Korean Adults with Tae-Eumin: A Cross-Sectional Study.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Association between the LIPG polymorphisms and serum lipid levels in the Maonan and Han populations.The journal of gene medicine · 2019Article
- A Single Nucleotide Polymorphism in the FADS1 Gene is Associated with Plasma Fatty Acid and Lipid Profiles and Might Explain Gender Difference in Body Fat Distribution.Lipids in health and disease · 2017Article
- Genome-Wide Association Study Reveals Four Loci for Lipid Ratios in the Korean Population and the Constitutional Subgroup.PloS one · 2017Article
- Genome-wide association study of serum lipids confirms previously reported associations as well as new associations of common SNPs within PCSK7 gene with triglyceride.Journal of human genetics · 2016Article
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5 authors.
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Abstract
backgroundAbnormal lipid concentrations are risk factors for atherosclerosis and cardiovascular disease. The pathological susceptibility to cardiovascular disease risks such as metabolic syndrome, diabetes mellitus, hypertension, insulin resistance, and so on differs between Sasang constitutional types.
methodsWe used multiple regression analyses to study the association between lipid-related traits and genetic variants from several genome-wide association studies according to Sasang constitutional types, considering that the Tae-Eum (TE) has predominant cardiovascular risk.
resultsBy analyzing 26 variants of 20 loci in two Korean populations (8,597 subjects), we found that 12 and 5 variants, respectively, were replicably associated with lipid levels and dyslipidemia risk. By analyzing TE and non-TE type (each 2,664 subjects) populations classified on the basis of Sasang constitutional medicine, we found that the minor allele effects of three variants enriched in TE type had a harmful influence on lipid risk (near apolipoprotein A-V (APOA5)-APOA4-APOC3-APOA1 on increased triglyceride: p = 8.90 × 10(-11), in APOE-APOC1-APOC4 on increased low-density lipoprotein cholesterol: p = 1.63 × 10(-5), and near endothelial lipase gene on decreased high-density lipoprotein cholesterol: p = 4.28 × 10(-3)), whereas those of three variants (near angiopoietin-like 3 gene, APOA5-APOA4-APOC3-APOA1, and near lipoprotein lipase gene on triglyceride and high-density lipoprotein cholesterol) associated in non-TE type had neutral influences because of a compensating effect.
conclusionsThese results implied that the minor allele effects of lipid-associated variants may predispose TE type subjects to high cardiovascular disease risk because of their genetic susceptibility to lipid-related disorders.
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