ArticleArchives of toxicology2014
Lung tumors in mice induced by "whole-life" inorganic arsenic exposure at human-relevant doses.
Article in Archives of toxicology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 66 citations in OpenAlex.
- Detection of Arsenic at Micromolar Concentrations and Remediation of Arsenic from Drinking Water with a Bemliese Teabag.ACS omega · 2026Article
- Update of the risk assessment of inorganic arsenic in food.EFSA journal. European Food Safety Authority · 2024Article
- Arsenic and Human Health: New Molecular Mechanisms For Arsenic-Induced Cancers.Current pollution reports · 2023Article
- Mechanisms of genotoxicity and proteotoxicity induced by the metalloids arsenic and antimony.Cellular and molecular life sciences : CMLS · 2023Review
- Polyadenylation of canonical histone H3.1 in carcinogenesis.Advances in pharmacology (San Diego, Calif.) · 2023Article
- Expression variation of OGG1 and HPRT gene and DNA damage in arsenic exposed industrial workers.PloS one · 2022Article
- Paradoxical effects of arsenic in the lungs.Environmental health and preventive medicine · 2021Review
- The Influence of Feed and Drinking Water on Terrestrial Animal Research and Study Replicability.ILAR journal · 2020Article
- Metals and molecular carcinogenesis.Carcinogenesis · 2020Review
- In utero exposure to arsenite contributes to metabolic and reproductive dysfunction in male offspring of CD-1 mice.Reproductive toxicology (Elmsford, N.Y.) · 2020Article
- Transplacental arsenic exposure produced 5-methylcytosine methylation changes and aberrant microRNA expressions in livers of male fetal mice.Toxicology · 2020Article
- Elevated Arsenic and Lead Concentrations in Natural Healing Clay Applied Topically as a Treatment for Ulcerative Dermatitis in Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2020Article
- Prostate Cancer Incidence in U.S. Counties and Low Levels of Arsenic in Drinking Water.International journal of environmental research and public health · 2020Article
- The Human Gut Microbiome's Influence on Arsenic Toxicity.Current pharmacology reports · 2019Article
- State of the science review of the health effects of inorganic arsenic: Perspectives for future research.Environmental toxicology · 2019Review
- Impact of prenatal arsenic exposure on chronic adult diseases.Systems biology in reproductive medicine · 2018Review
- Multi-generational impacts of arsenic exposure on genome-wide DNA methylation and the implications for arsenic-induced skin lesions.Environment international · 2018Article
- Article
- Cellular and Molecular Effects of Prolonged Low-Level Sodium Arsenite Exposure on Human Hepatic HepaRG Cells.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
- Long-Term Health Effects and Underlying Biological Mechanisms of Developmental Exposure to Arsenic.Current environmental health reports · 2018Review
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5 authors at 2 institutions in 1 country.
Funding
Abstract
In mice, inorganic arsenic in the drinking water in the parts per million range via the dam during in utero life or with whole-life exposure is a multi-site carcinogen in the offspring. However, human arsenic exposure is typically in the parts per billion (ppb) range. Thus, we studied "whole-life" inorganic arsenic carcinogenesis in mice at levels more relevant to humans. Breeder male and female CD1 mice were exposed to 0, 50, 500 or 5,000 ppb arsenic (as sodium arsenite) in the drinking water for 3 weeks prior to breeding, during pregnancy and lactation, and after weaning (at week 3) groups of male and female offspring (initial n = 40) were exposed for up to 2 years. Tumors were assessed in these offspring. Arsenic exposure had no effect on pregnant dam weights or water consumption, litter size, offspring birthweight or weight at weaning compared to control. In male offspring mice, arsenic exposure increased (p < 0.05) bronchiolo-alveolar tumor (adenoma or carcinoma) incidence at 50-ppb group (51 %) and 500-ppb group (54 %), but not at 5,000-ppb group (28 %) compared to control (22 %). These arsenic-induced bronchiolo-alveolar tumors included increased (p < 0.05) carcinoma at 50-ppb group (27 %) compared to controls (8 %). An increase (p < 0.05) in lung adenoma (25 %) in the 50-ppb group compared to control (11 %) occurred in female offspring. Thus, in CD1 mice whole-life arsenic exposure induced lung tumors at human-relevant doses (i.e., 50 and 500 ppb).
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