ArticleSoft matter2014
A bio-inspired microstructure induced by slow injection moulding of cylindrical block copolymers.
Article in Soft matter, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Design and Fabrication of 3D-Printed Biomimetic Fiber-Reinforced Polymeric Aortic Valves for Improved Stress Distribution.Annals of biomedical engineering · 2026Article
- Polymeric Heart Valves Will Displace Mechanical and Tissue Heart Valves: A New Era for the Medical Devices.International journal of molecular sciences · 2023Review
- Engineering Efforts to Refine Compatibility and Duration of Aortic Valve Replacements: An Overview of Previous Expectations and New Promises.Frontiers in cardiovascular medicine · 2022Review
- Mechanical considerations for polymeric heart valve development: Biomechanics, materials, design and manufacturing.Biomaterials · 2019Review
- A Computational Tool for the Microstructure Optimization of a Polymeric Heart Valve Prosthesis.Journal of biomechanical engineering · 2016Article
- Hemocompatibility of styrenic block copolymers for use in prosthetic heart valves.Journal of materials science. Materials in medicine · 2016Article
- Fluid dynamic characterization of a polymeric heart valve prototype (Poli-Valve) tested under continuous and pulsatile flow conditions.The International journal of artificial organs · 2015Article
- Physical Characterization and Platelet Interactions under Shear Flows of a Novel Thermoset Polyisobutylene-based Co-polymer.ACS applied materials & interfaces · 2015Article
- Structural changes of block copolymers with bi-modal orientation under fast cyclical stretching as observed by synchrotron SAXS.Soft matter · 2015Article
- A Newly Developed Tri-Leaflet Polymeric Heart Valve Prosthesis.Journal of mechanics in medicine and biology · 2015Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
It is well known that block copolymers with cylindrical morphology show alignment with shear, resulting in anisotropic mechanical properties. Here we show that well-ordered bi-directional orientation can be achieved in such materials by slow injection moulding. This results in a microstructure, and anisotropic mechanical properties, similar to many natural tissues, making this method attractive for engineering prosthetic fibrous tissues. An application of particular interest to us is prosthetic polymeric heart valve leaflets, mimicking the shape, microstructure and hence performance of the native valve. Anisotropic layers have been observed for cylinder-forming block copolymers centrally injected into thin circular discs. The skin layers exhibit orientation parallel to the flow direction, whilst the core layer shows perpendicularly oriented domains; the balance of skin to core layers can be controlled by processing parameters such as temperature and injection rate. Heart valve leaflets with a similar layered structure have been prepared by injection moulding. Numerical modelling demonstrates that such complex orientation can be explained and predicted by the balance of shear and extensional flow.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.