ArticleJournal of gastroenterology2015
Possible involvement of Toll-like receptor 7 in the development of type 1 autoimmune pancreatitis.
Article in Journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Single-cell multi-omics analysis revealed the expansion of age-associated B cells in the pancreas of type 1 autoimmune pancreatitis patients.Genome medicine · 2025Article
- IgG4-related Disease: Recent Topics on Immunological Aspects of This Disorder and Their Application in New Treatment Strategies.Internal medicine (Tokyo, Japan) · 2025Review
- Microbiota in the Natural History of Pancreatic Cancer: From Predisposition to Therapy.Cancers · 2022Review
- Current status of type 1 (IgG4-related) autoimmune pancreatitis.Journal of gastroenterology · 2022Review
- CD163+ M2 Macrophages Promote Fibrosis in IgG4-Related Disease Via Toll-like Receptor 7/Interleukin-1 Receptor-Associated Kinase 4/NF-κB Signaling.Arthritis & rheumatology (Hoboken, N.J.) · 2022Article
- Microbiota in Pancreatic Diseases: A Review of the Literature.Journal of clinical medicine · 2021Review
- Biomarkers in autoimmune pancreatitis and immunoglobulin G4-related disease.World journal of gastroenterology · 2021Article
- Intestinal Dysbiosis and Autoimmune Pancreatitis.Frontiers in immunology · 2021Review
- Gut microbiome alterations in type 1 autoimmune pancreatitis after induction of remission by prednisolone.Clinical and experimental immunology · 2020Article
- Review
- Activated M2 Macrophages Contribute to the Pathogenesis of IgG4-Related Disease via Toll-like Receptor 7/Interleukin-33 Signaling.Arthritis & rheumatology (Hoboken, N.J.) · 2020Article
- Abundant a proliferation-inducing ligand (APRIL)-producing macrophages contribute to plasma cell accumulation in immunoglobulin G4-related disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2019Article
- Response to the Letter by Poddighe et al. regarding our manuscript "Basophils activated via TLR signaling may contribute to pathophysiology of type 1 autoimmune pancreatitis".Journal of gastroenterology · 2018Article
- IgG4-Related Disease: Beyond Glucocorticoids.Drugs & aging · 2018Review
- Clinical and pathophysiological aspects of type 1 autoimmune pancreatitis.Journal of gastroenterology · 2018Review
- Basophils activated via TLR signaling may contribute to pathophysiology of type 1 autoimmune pancreatitis.Journal of gastroenterology · 2018Article
- Gut Microbiota-Immune System Crosstalk and Pancreatic Disorders.Mediators of inflammation · 2018Review
- Current perspectives on autoimmune pancreatitis and IgG4-related disease.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2018Review
- Sclerosing Esophagitis with IgG4-positive Plasma Cell Infiltration.Internal medicine (Tokyo, Japan) · 2017Article
- Interleukin-33 produced by M2 macrophages and other immune cells contributes to Th2 immune reaction of IgG4-related disease.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHigh serum immunoglobulin G4 (IgG4) levels and IgG4-positive plasma cell infiltration are characteristic of type 1 autoimmune pancreatitis (AIP). It is unclear whether innate immunity is a cause of type 1 AIP; the possible involvement of microbial infection has been suggested in its pathogenesis. To clarify the pathogenesis of type 1 AIP, we investigated Toll-like receptors (TLRs) in type 1 AIP patients.
methodsWe studied nine cases of type 1 AIP with ten cases of alcoholic chronic pancreatitis (ACP) and three of the samples from non-tumorous lesion of neuroendocrine tumor (NET) as control subjects. We counted the number of TLR1-11-positive cells immunohistochemically stained with anti-TLR1-11 antibodies. To identify TLR-positive cells in pancreata from type 1 AIP patients, we used a double-immunofluorescence method and counted the numbers of identifiable CD68-, CD163-, CD123-, and CD20-positive cells.
resultsIn type 1 AIP, TLR7 (8.815 ± 1.755), TLR8 (3.852 ± 1.489), and TLR10 (3.852 ± 0.921) were highly expressed. Only the ratio of TLR7 per monocyte was significantly higher in type 1 AIP (0.053 ± 0.012) than in ACP (0.007 ± 0.004; p < 0.01) and non-tumorous lesion of NET (0.000 ± 0.000; p < 0.01). In type 1 AIP, the CD163 to TLR7 ratio (0.789 ± 0.031) was significantly higher both than that of CD123 to TLR7 ratio (0.034 ± 0.006; p < 0.001) and CD20 to TLR7 ratio (0.029 ± 0.010; p < 0.001).
conclusionsTLR7 might be key pattern-recognition receptors involved in the development of type 1 AIP.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.