Trial reportJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2014
Development and validation of a patient-tailored dose regime in myocardial perfusion imaging using CZT-SPECT.
Trial report in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Development and validation of a patient-tailored dose regime in myocardial perfusion imaging using conventional SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Trial
- An Algorithm for Individual Dosage in Cadmium-Zinc-Telluride SPECT-Gated Radionuclide Angiography.Diagnostics (Basel, Switzerland) · 2021Article
- Body weight-dependent Rubidium-82 activity results in constant image quality in myocardial perfusion imaging with PET.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- The next step in standardizing SPECT myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Patient-specific SPECT imaging protocols to standardize image noise.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Single Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging Guidelines: Instrumentation, Acquisition, Processing, and Interpretation.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Review
- Value of automatic patient motion detection and correction in myocardial perfusion imaging using a CZT-based SPECT camera.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- The very hungry caterpillar and the ongoing effort to reduce radiation in myocardial perfusion scintigraphy: Have we become the beautiful butterfly?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Effect of a patient-specific minimum activity in stress myocardial perfusion imaging using CZT-SPECT: Prognostic value, radiation dose, and scan outcome.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Patient-specific activity or scan-time in SPECT myocardial perfusion imaging: A hands-on approach.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Performance of cardiac cadmium-zinc-telluride gamma camera imaging in coronary artery disease: a review from the cardiovascular committee of the European Association of Nuclear Medicine (EANM).European journal of nuclear medicine and molecular imaging · 2016Review
- NovelNuclear medicine and biology · 2016Article
- Patient-specific tracer activity in MPI SPECT: A hands-on approach.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- Patient centered imaging and the dose of radiopharmaceuticals.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- Prognostic value of normal stress-only myocardial perfusion imaging: a comparison between conventional and CZT-based SPECT.European journal of nuclear medicine and molecular imaging · 2016Article
- Can advances in nuclear cardiology hardware overcome the challenges of imaging obese patients?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGuidelines for SPECT myocardial perfusion imaging (MPI) traditionally recommend a fixed tracer dose. Yet, clinical practice shows degraded image quality in heavier patients. The aim was to optimize and validate the tracer dose and scan time to obtain a constant image quality less dependent on patients' physical characteristics.
methods125 patients underwent Cadmium Zinc Telluride (CZT)-SPECT stress MPI using a fixed Tc-99m-tetrofosmin tracer dose. Image quality was scored by three physicians on a 4-point grading scale and related to the number of photon counts normalized to tracer dose and scan time. Counts were correlated with various patient-specific parameters dealing with patient size and weight to find the best predicting parameter. From these data, a formula to provide constant image quality was derived, and subsequently tested in 92 new patients.
resultsDegradation in image quality and photon counts was observed for heavier patients for all patients' specific parameters (P < .01). We found body weight to be the best-predicting parameter for image quality and derived a new dose formula. After applying this new body weight-depended tracer dose and scan time in a new group, image quality was found to be constant (P > .19) in all patients.
conclusionsAlso in CZT SPECT image quality decreases with weight. The use of a tracer dose and scan time that depends linearly on patient's body weight corrected for the varying image quality in CZT-SPECT MPI. This leads to better radiation exposure justification.
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