ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2014
Reduced dopamine transporter functioning induces high-reward risk-preference consistent with bipolar disorder.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Dopamine transporter knockdown mice in the behavioral pattern monitor: A robust, reproducible model for mania-relevant behaviors.Pharmacology, biochemistry, and behavior · 2019Pooled it
- Evidence for pro-cognitive benefits of cannabinoids in people with bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Trial
- Chemogenetic inhibition of the anterior cingulate cortex increases safe decision-making in aged mice performing the Iowa Gambling Task.Psychopharmacology · 2026Article
- Mesolimbic Dopaminergic Encoding of Decision Value: Linking Phenotype-Specific Signals to Strategic Adaptation.Neuroscience bulletin · 2026Article
- Reinforcement learning impairment in individuals with euthymic bipolar I disorder with a history of psychosis.European archives of psychiatry and clinical neuroscience · 2026Article
- Neurocomputational mechanisms of reward-based online mood regulation in adolescents with bipolar disorder and major depressive disorder.Psychoradiology · 2026Article
- Chronic cannabis use in people with bipolar disorder is associated with comparable decision-making and functional outcome to healthy participants.Translational psychiatry · 2025Article
- Maximising translational value of the Iowa gambling task in preclinical studies through the use of the rodent touchscreen.Frontiers in psychiatry · 2025Review
- Genetic loss of the dopamine transporter significantly impacts behavioral and molecular responses to sub-chronic stress in mice.Frontiers in molecular neuroscience · 2024Article
- Proceedings of the 2022 annual meeting of the Fetal Alcohol Spectrum Disorders study group.Alcohol (Fayetteville, N.Y.) · 2023Article
- CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice.Translational psychiatry · 2023Article
- The association between risky decision making and cocaine conditioned place preference is moderated by sex.Drug and alcohol dependence · 2021Article
- Electrophysiological biomarkers of behavioral dimensions from cross-species paradigms.Translational psychiatry · 2021Article
- Enlightened: addressing circadian and seasonal changes in photoperiod in animal models of bipolar disorder.Translational psychiatry · 2021Review
- The relationship between cannabis use and cognition in people with bipolar disorder: A systematic scoping review.Psychiatry research · 2021Article
- Risk-Based Decision Making: A Systematic Scoping Review of Animal Models and a Pilot Study on the Effects of Sleep Deprivation in Rats.Clocks & sleep · 2021Article
- Cannabis Use and Mental Illness: Understanding Circuit Dysfunction Through Preclinical Models.Frontiers in psychiatry · 2021Review
- Risky decision-making following prefrontal D1 receptor manipulation.Translational neuroscience · 2021Article
- Ablation of Ventral Midbrain/Pons GABA Neurons Induces Mania-like Behaviors with Altered Sleep Homeostasis and Dopamine DiScience · 2020Article
- Convergent neural substrates of inattention in bipolar disorder patients and dopamine transporter-deficient mice using the 5-choice CPT.Bipolar disorders · 2020Article
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8 authors.
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Abstract
Individuals with bipolar disorder (BD) exhibit deleterious decision making, negatively impacting their lives. Such aberrant decision making can be quantified using the Iowa Gambling Task (IGT), which requires choosing between advantageous and disadvantageous options based on different reward/punishment schedules. The mechanisms underlying this behavioral deficit are unknown, but may include the reduced dopamine transporter (DAT) functioning reported in BD patients. Using both human and mouse IGTs, we tested whether reduced DAT functioning would recreate patterns of deficient decision making of BD patients. We assessed the IGT performance of 16 BD subjects (7 female) and 17 healthy control (HC) subjects (12 female). We recorded standard IGT performance measures and novel post-reward and post-punishment decision-making strategies. We characterized a novel single-session mouse IGT using C57BL/6J mice (n = 44). The BD and HC IGT performances were compared with the effects of chronic (genetic knockdown (KD; n = 31) and wild-type (n = 28) mice) and acute (C57BL/6J mice (n = 89) treated with the DAT inhibitor GBR12909) reductions of DAT functioning in mice performing this novel IGT. BD patients exhibited impaired decision making compared with HC subjects. Both the good-performing DAT KD and GBR12909-treated mice exhibited poor decision making in the mouse IGT. The deficit of each population was driven by high-reward sensitivity. The single-session mouse IGT measures dynamic risk-based decision making similar to humans. Chronic and acute reductions of DAT functioning in mice impaired decision-making consistent with poor IGT performance of BD patients. Hyperdopaminergia caused by reduced DAT may impact poor decision making in BD patients, which should be confirmed in future studies.
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