ArticleJournal of experimental botany2014
Different and overlapping functions of Arabidopsis LHT6 and AAP1 transporters in root amino acid uptake.
Article in Journal of experimental botany, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 92 citations in OpenAlex.
- NtANTL2 overexpression regulates starch-related and nitrogen metabolism in tobacco plants.BMC plant biology · 2025Article
- Bacterial osmoprotectants-a way to survive in saline conditions and potential crop allies.FEMS microbiology reviews · 2025Review
- Genome-wide identification ofFrontiers in genetics · 2025Article
- Amino acids biosynthesis in root hair development: a mini-review.Biochemical Society transactions · 2024Review
- UMAMIT44 is a key player in glutamate export from Arabidopsis chloroplasts.The Plant cell · 2024Article
- Genome-wide identification and comparative analysis of the Amino Acid Transporter (AAT) gene family and their roles during Phaseolus vulgaris symbioses.Functional & integrative genomics · 2024Article
- Why did glutamate, GABA, and melatonin become intercellular signalling molecules in plants?eLife · 2023Review
- Fluorescent-Dye-Labeled Amino Acids for Real-Time Imaging inMolecules (Basel, Switzerland) · 2023Article
- ThePlants (Basel, Switzerland) · 2023Article
- Article
- Identification, Phylogenetic and Expression Analyses of theInternational journal of molecular sciences · 2022Article
- Tissue specific expression of UMAMIT amino acid transporters in wheat.Scientific reports · 2022Article
- Low phosphorus induces differential metabolic responses in eucalyptus species improving nutrient use efficiency.Frontiers in plant science · 2022Article
- Exogenous Cysteine Improves Mercury Uptake and Tolerance inFrontiers in plant science · 2022Article
- Genome-Wide Identification and Functional Analysis of Lysine Histidine Transporter (LHT) Gene Families in Maize.Genetics research · 2022Article
- Promoter profiling of Arabidopsis amino acid transporters: clues for improving crops.Plant molecular biology · 2021Review
- Genome-Wide Analysis ofPlants (Basel, Switzerland) · 2021Article
- The tea plant CsLHT1 and CsLHT6 transporters take up amino acids, as a nitrogen source, from the soil of organic tea plantations.Horticulture research · 2021Article
- Identification, systematic evolution and expression analyses of the AAAP gene family in Capsicum annuum.BMC genomics · 2021Article
- Nitrogen Uptake in Plants: The Plasma Membrane Root Transport Systems from a Physiological and Proteomic Perspective.Plants (Basel, Switzerland) · 2021Review
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Plants acquire nitrogen in the form of amino acids from the soil, and transport proteins located in the plasma membrane of root cells are required for this process. It was found that the Arabidopsis lysine-histidine-like transporter LHT6 is expressed in root cells important for amino acid uptake, including the epidermis, root hairs, and cortex. Transport studies with lht6 mutants using high levels of amino acids demonstrated that LHT6 is in fact involved in amino acid uptake. To determine if LHT6 plays a role in nitrogen acquisition at soil amino acid concentrations, growth and uptake studies were performed with low levels of toxic amino acid analogues and radiolabelled amino acids, respectively. In addition, mutants of AAP1, another root amino acid transporter, and lht6/aap1 double mutants were examined. The results showed that LHT6 is involved in uptake of acidic amino acids, glutamine and alanine, and probably phenylalanine. LHT6 seems not to transport basic or other neutral amino acids, or, alternatively, other transporters might compensate for eliminated LHT6 function. Previous studies suggested that AAP1 only takes up amino acids at high concentrations; however, here it is demonstrated that the transporter functions in acquisition of glutamate and neutral amino acids when present at soil concentrations. When comparing the characterized root uptake systems, it appears that transporters both with overlapping substrate specificity and with preference for specific substrates are required to access the soil amino acid pool.
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