ArticleMicrobial ecology2014
Effect of intestinal microbiota alteration on hepatic damage in rats with acute rejection after liver transplantation.
Article in Microbial ecology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 58 citations in OpenAlex.
- The gut microbiome and allograft outcomes: implications for heart transplantation.The Journal of clinical investigation · 2026Review
- 2bRAD-M reveals circulating microbiome in chronic antibody-mediated rejection (CAMR) and IgA nephropathy (IgAN) after kidney transplantation.BMC microbiology · 2025Article
- The Microbiome and Pediatric Transplantation.Journal of the Pediatric Infectious Diseases Society · 2024Review
- A Comprehensive Overview of the Past, Current, and Future Randomized Controlled Trials in Hepatic Encephalopathy.Medicina (Kaunas, Lithuania) · 2023Review
- Review
- The role of gut microbiota in liver regeneration.Frontiers in immunology · 2022Review
- Influence of the microbiome on solid organ transplant survival.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2021Review
- The role of the gut microbiome in graft fibrosis after pediatric liver transplantation.Human genetics · 2021Review
- Effects of Gut Metabolites and Microbiota in Healthy and Marginal Livers Submitted to Surgery.International journal of molecular sciences · 2020Review
- Review
- Bioinformatic analysis of peripheral blood RNA-sequencing sensitively detects the cause of late graft loss following overt hyperglycemia in pig-to-nonhuman primate islet xenotransplantation.Scientific reports · 2019Article
- Characterization and evolution of intestine injury at the anhepatic phase in portal hypertensive rats.Experimental and therapeutic medicine · 2018Article
- Gut microbial balance and liver transplantation: alteration, management, and prediction.Frontiers of medicine · 2018Review
- Organ transplantation and gut microbiota: current reviews and future challenges.American journal of translational research · 2018Review
- Characteristics of fecal microbial communities in patients with non-anastomotic biliary strictures after liver transplantation.World journal of gastroenterology · 2017Observational
- Network analysis of gut microbiota literature: an overview of the research landscape in non-human animal studies.The ISME journal · 2017Review
- Impact of environmental factors on alloimmunity and transplant fate.The Journal of clinical investigation · 2017Review
- Current status of the microbiome in renal transplantation.Current opinion in nephrology and hypertension · 2016Review
- Implications of microbiota and bile acid in liver injury and regeneration.Journal of hepatology · 2015Review
- Gut microbiota and allogeneic transplantation.Journal of translational medicine · 2015Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The previous studies all focus on the effect of probiotics and antibiotics on infection after liver transplantation. Here, we focus on the effect of gut microbiota alteration caused by probiotics and antibiotics on hepatic damage after allograft liver transplantation. Brown-Norway rats received saline, probiotics, or antibiotics via daily gavage for 3 weeks. Orthotopic liver transplantation (OLT) was carried out after 1 week of gavage. Alteration of the intestinal microbiota, liver function and histopathology, serum and liver cytokines, and T cells in peripheral blood and Peyer's patch were evaluated. Distinct segregation of fecal bacterial diversity was observed in the probiotic group and antibiotic group when compared with the allograft group. As for diversity of intestinal mucosal microbiota and pathology of intestine at 2 weeks after OLT, antibiotics and probiotics had a significant effect on ileum and colon. The population of Lactobacillus and Bifidobacterium in the probiotic group was significantly greater than the antibiotic group and the allograft group. The liver injury was significantly reduced in the antibiotic group and the probiotic group compared with the allograft group. The CD4/CD8 and Treg cells in Peyer's patch were decreased in the antibiotic group. The intestinal Treg cell and serum and liver TGF-β were increased markedly while CD4/CD8 ratio was significantly decreased in the probiotic group. It suggested that probiotics mediate their beneficial effects through increase of Treg cells and TGF-β and deduction of CD4/CD8 in rats with acute rejection (AR) after OLT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.