ArticleMolecular and cellular endocrinology2014
A steroid receptor coactivator acts as the DNA-binding partner of the methoprene-tolerant protein in regulating juvenile hormone response genes.
Article in Molecular and cellular endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39 citing papers in PubMed.
- Juvenile hormone receptor relies on conserved domain interfaces for dimerization-dependent activity.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Characterization of the Crustacean Methyl Farnesoate Transcriptional Signaling Genes.International journal of molecular sciences · 2026Article
- Involvement of Taiman in juvenile hormone signaling controlling sexual maturation in a male moth.Current research in insect science · 2026Article
- Juvenile hormone induces phosphorylation of insulin/insulin-like growth factor signaling proteins in previtellogenic Aedes aegypti mosquitoes.Insect science · 2025Article
- Membrane-localized MET engages PVR to mediate extranuclear juvenile hormone signaling inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- 20E-inducedProceedings of the National Academy of Sciences of the United States of America · 2025Article
- The seminal vesicle is a juvenile hormone-responsive tissue in adult maleOpen biology · 2024Article
- Methoprene-Tolerant (Met) Acts as Methyl Farnesoate Receptor to Regulate Larva Metamorphosis in Mud Crab,International journal of molecular sciences · 2024Article
- Tai/NCOA2 suppresses the Hedgehog pathway by directly targeting the transcription factor Ci/GLI.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The Juvenile-Hormone-Responsive FactorBiomolecules · 2023Article
- Juvenile hormone receptor Methoprene tolerant: Functions and applications.Vitamins and hormones · 2023Article
- Unique peptidic agonists of a juvenile hormone receptor with species-specific effects on insect development and reproduction.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Role of Methoprene-tolerant in the regulation of oogenesis in Dipetalogaster maxima.Scientific reports · 2022Article
- Non-genomic action of juvenile hormone modulates the synthesis of 20-hydroxyecdysone inScience bulletin · 2022Article
- Purification of an insect juvenile hormone receptor complex enables insights into its post-translational phosphorylation.The Journal of biological chemistry · 2021Article
- Detection of juvenile hormone agonists by a new reporter gene assay using yeast expressing Drosophila methoprene-tolerant.FEBS open bio · 2021Article
- Regulation of Juvenile Hormone on Summer Diapause ofInsects · 2021Article
- Virtual screening identifies a novel piperazine-based insect juvenile hormone agonist.Journal of pesticide science · 2021Article
- Reporter gene assays for screening and identification of novel molting hormone- and juvenile hormone-like chemicals.Journal of pesticide science · 2021Article
- Aedes aegypti post-emergence transcriptome: Unveiling the molecular basis for the hematophagic and gonotrophic capacitation.PLoS neglected tropical diseases · 2021Article
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7 authors.
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Abstract
Methoprene-tolerant (Met) protein is a juvenile hormone (JH) receptor in insects. JH-bound Met forms a complex with the βFtz-F1-interacting steroid receptor coactivator (FISC) and together they regulate JH response genes in mosquitoes. Both proteins contain basic helix-loop-helix (bHLH) and PAS motifs. Here we demonstrated that FISC is the obligatory partner of Met for binding to JH-response elements (JHREs). Met or FISC alone could not bind a previously characterized JHRE, while formation of the Met-FISC complex was necessary and sufficient to bind to the JHRE. This binding required participation of the DNA-binding domains of both Met and FISC. The optimal DNA sequence recognized by Met and FISC contained a core consensus sequence GCACGTG. While formation of the Met-FISC complex in mosquito cells was induced by JH, heterodimerization and DNA binding of bacterially expressed Met and FISC were JH-independent, implying that additional mosquito proteins were required to modulate formation of the receptor complex.
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