ArticlePloS one2014
Effects of different tissue microenvironments on gene expression in breast cancer cells.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Tumor microenvironment and exosomes in brain metastasis: Molecular mechanisms and clinical application.Frontiers in oncology · 2022Review
- Foe or friend? Janus-faces of the neurovascular unit in the formation of brain metastases.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Review
- [Tumor Cells and Micro-environment in Brain Metastases].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2016Review
- Quantification of cancer cell extravasation in vivo.Nature protocols · 2016Article
- PHOX2B is a suppressor of neuroblastoma metastasis.Oncotarget · 2016Article
- 'Cut from the same cloth': Shared microsatellite variants among cancers link to ectodermal tissues-neural tube and crest cells.Oncotarget · 2015Article
- CRABP1 is associated with a poor prognosis in breast cancer: adding to the complexity of breast cancer cell response to retinoic acid.Molecular cancer · 2015Article
- Interpretation of immunohistochemistry data of tumor should consider microenvironmental factors.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Mesenchymal stromal cells derived from acute myeloid leukemia bone marrow exhibit aberrant cytogenetics and cytokine elaboration.Blood cancer journal · 2015Article
- Efficacy of Carboplatin Alone and in Combination with ABT888 in Intracranial Murine Models of BRCA-Mutated and BRCA-Wild-Type Triple-Negative Breast Cancer.Molecular cancer therapeutics · 2015Article
- Molecular and Genetic Predictors of Breast-to-Brain Metastasis: Review and Case Presentation.Cureus · 2015Review
- MCL-1, BCL-XL and MITF Are Diversely Employed in Adaptive Response of Melanoma Cells to Changes in Microenvironment.PloS one · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
In metastasis, circulating tumor cells penetrate the walls of blood vessels and enter the metastatic target tissue, thereby becoming exposed to novel and relatively unsupportive microenvironments. In the new microenvironments, the tumor cells often remain in a dormant state indefinitely and must adapt before they are able to successfully colonize the tissue. Very little is known about this adaptive process. We studied temporal changes in gene expression when breast cancer cells adapt to survive and grow on brain, bone marrow, and lung tissue maintained in an in vivo culture system, as models of the metastatic colonization of these tissues. We observed the transient activation of genes typically associated with homeostasis and stress during the initial stages of adaptation, followed by the activation of genes that mediate more advanced functions, such as elaboration of cell morphology and cell division, as the cells adapted to thrive in the host tissue microenvironment. We also observed the temporary induction of genes characteristic of the host tissue, which was particularly evident when tumor cells were grown on brain tissue. These early transient gene expression events suggest potential points of therapeutic intervention that are not evident in data from well-established tumors.
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