ArticleEndocrinology2014
Intrinsic expression of a multiexon type 3 deiodinase gene controls zebrafish embryo size.
Article in Endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Patterning and Development of Photoreceptors in the Human Retina.Frontiers in cell and developmental biology · 2022Review
- Deiodinases: How Nonmammalian Research Helped Shape Our Present View.Endocrinology · 2021Review
- Effect of Preeclampsia on Ultrastructure of Thyroid Gland, Hepatic Type 1 Iodothyronine Deiodinase, and Thyroid Hormone Levels in Rats.BioMed research international · 2021Article
- Effects of thyroid hormone disruption on the ontogenetic expression of thyroid hormone signaling genes in developing zebrafish (Danio rerio).General and comparative endocrinology · 2019Article
- Thyroid hormone signaling specifies cone subtypes in human retinal organoids.Science (New York, N.Y.) · 2018Article
- Transcriptomic and phenotypic profiling in developing zebrafish exposed to thyroid hormone receptor agonists.Reproductive toxicology (Elmsford, N.Y.) · 2018Article
- Mechanisms of Photoreceptor Patterning in Vertebrates and Invertebrates.Trends in genetics : TIG · 2016Review
- Deiodinase knockdown during early zebrafish development affects growth, development, energy metabolism, motility and phototransduction.PloS one · 2015Article
Corrections and comments
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Authors and funding
16 authors at 6 institutions in 2 countries.
Funding
Abstract
Thyroid hormone is a master regulator of differentiation and growth, and its action is terminated by the enzymatic removal of an inner-ring iodine catalyzed by the selenoenzyme type 3 deiodinase (dio3). Our studies of the zebrafish reveal that the dio3 gene is duplicated in this species and that embryonic deiodination is an important determinant of embryo size. Although both dio3 paralogs encode enzymatically active proteins with high affinity for thyroid hormones, their anatomic patterns of expression are markedly divergent and only embryos with knockdown of dio3b, a biallelically expressed selenoenzyme expressed in the developing central nervous system, manifest severe thyroid hormone-dependent growth restriction at 72 hours post fertilization. This indicates that the embryonic deficiency of dio3, once considered only a placental enzyme, causes microsomia independently of placental physiology and raises the intriguing possibility that fetal abnormalities in human deiodination may present as intrauterine growth retardation. By mapping the gene structures and enzymatic properties of all four zebrafish deiodinases, we also identify dio3b as the first multiexon dio3 gene, containing a large intron separating its open reading frame from its selenocysteine insertion sequence (SECIS) element.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.