ArticlePloS one2014
The relationship between frontal lobe lesions, course of post-stroke depression, and 1-year prognosis in patients with first-ever ischemic stroke.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04318951 (Impact of Intensive Social Interaction on Post-Stroke Depression in Individuals With Aphasia), which is not on this map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Intensive Social Interaction on Post-Stroke Depression in Individuals With Aphasia
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Prevalence, Trajectory, and Factors Associated With Patient-Reported Nonmotor Outcomes After Stroke: A Systematic Review and Meta-Analysis.JAMA network open · 2025Pooled it
- Prevalence and natural history of depression after stroke: A systematic review and meta-analysis of observational studies.PLoS medicine · 2023Pooled it
- Imaging Markers of Post-Stroke Depression and Apathy: a Systematic Review and Meta-Analysis.Neuropsychology review · 2017Pooled it
- Multi-omics integrative analysis reveals novel genetic loci and candidate genes for ischemic stroke.Molecular therapy. Nucleic acids · 2025Article
- Development and interpretation of a machine learning risk prediction model for post-stroke depression in a Chinese population.Scientific reports · 2025Article
- Genetic Polymorphisms and Gene-Environment Interactions in Persistent Post-Stroke Depression.Neuropsychiatric disease and treatment · 2025Article
- A one-year relapse prediction model for acute ischemic stroke (AIS) based on clinical big data.Heliyon · 2024Article
- Post-stroke arrhythmia could be a potential predictor for post-stroke depression.Scientific reports · 2024Article
- In-Hospital Symptoms of Depression and Anxiety are Strong Risk Factors for Post-Stroke Depression 90 Days After Ischemic Stroke.The Neurohospitalist · 2023Article
- Nomogram for Persistent Post-Stroke Depression and Decision Curve Analysis.Clinical interventions in aging · 2022Article
- Late Life Depression: The Essentials and the Essential Distinctions.Focus (American Psychiatric Publishing) · 2021Article
- Depression and functional disability in stroke patients.Journal of public health research · 2020Article
- Assessment of the Progression of Poststroke Depression in Ischemic Stroke Patients Using the Patient Health Questionnaire-9.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2020Article
- Predictors of Remission of Early-Onset Poststroke Depression and the Interaction Between Depression and Cognition During Follow-Up.Frontiers in psychiatry · 2018Article
- A Study of the Brain Abnormalities of Post-Stroke Depression in Frontal Lobe Lesion.Scientific reports · 2017Article
- Age-Related Frontal Periventricular White Matter Hyperintensities and miR-92a-3p Are Associated with Early-Onset Post-Stroke Depression.Frontiers in aging neuroscience · 2017Article
- Post-Stroke Depression: Impact of Lesion Location and Methodological Limitations-A Topical Review.Frontiers in neurology · 2017Review
- Magnitude of multimorbidity and associated factors among stroke survivors in public hospitals of Ethiopia.Journal of multimorbidity and comorbidityArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeMost studies on post-stroke depression (PSD) have focused on a certain time point after stroke instead of the time course of PSD. The aim of this study was to determine the relationship between frontal lobe lesions, course of PSD over a year following the stroke onset, and the 1-year prognosis in patients with first-ever ischemic stroke.
methodsA total of 1067 patients from the prospective cohort study on the incidence and outcome of patients with post stroke depression in China who were diagnosed with first-ever ischemic stroke and attended 4 follow-up visits at 14±2 days, 3 months, 6 months, and 1 year after stroke onset, were enrolled in the study. PSD was diagnosed according to DSM-IV. The course of PSD was divided into the following two categories: persistent/recurrent depression and no/transient depression. Patients with any ischemic lesion responsible for the indexed stroke event located in the frontal lobe were defined as patients with frontal lobe lesions. Modified Rankin Scale (mRS) ≥2 at 1-year was considered to be poor prognosis.
resultsThere were 109 patients with and 958 patients without frontal lobe lesions that formed the frontal lobe (FL) and no-frontal lobe (NFL) groups, respectively. After adjusting for confounding variables, frontal lobe lesion was significantly associated with persistent/recurrent PSD (OR 2.025, 95%CI 1.039-3.949). Overall, 32.7% of patients in the FL group had poor prognosis at 1- year compared with 22.7% in the NFL group (P = 0.021). Compared with no/transient depression, persistent/recurrent depression was found to be an independent predictor of poor prognosis at 1-year both in FL and NFL groups.
conclusionsLong-term and periodical screening, evaluation and treatment are needed for PSD after the onset of ischemic stroke, particularly for patients with frontal lobe infarction.
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