ArticlePsychosomatic medicine
Early adverse life events and resting state neural networks in patients with chronic abdominal pain: evidence for sex differences.
Article in Psychosomatic medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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39 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Functional changes of default mode network and structural alterations of gray matter in patients with irritable bowel syndrome: a meta-analysis of whole-brain studies.Frontiers in neuroscience · 2023Pooled it
- Gender differences in functional connectivities between insular subdivisions and selective pain-related brain structures.The journal of headache and pain · 2018Trial
- Early life stress and the pathogenesis of visceral hypersensitivity: mechanisms and implications for disorders of gut-brain interaction.Frontiers in cell and developmental biology · 2026Review
- Analysis of anticancer drug associated adverse reactions in depressive patients from vigibase.Scientific reports · 2025Article
- Altered Sigmoid Mucosal Innervation and Mast Cell Proximity to Sensory Nerve Fibers Are Associated With Symptom Severity in Patients With Irritable Bowel Syndrome.Neurogastroenterology and motility · 2025Article
- Multi-omics analysis reveal clinical-gut-brain interactions in female ibs patients with adverse childhood experiences.Biology of sex differences · 2025Article
- Exploration of TCM Comprehensive Treatment of Irritable Bowel Syndrome Based on Pathophysiological Mechanism.International journal of general medicine · 2025Review
- Interoceptive Processing in Functional Gastrointestinal Disorders.International journal of molecular sciences · 2024Review
- Racism as a Source of Pain.Journal of general internal medicine · 2023Review
- The neurobiology of irritable bowel syndrome.Molecular psychiatry · 2023Review
- Connecting dots in disorders of gut-brain interaction: the interplay of stress and sex hormones in shaping visceral pain.Frontiers in psychiatry · 2023Review
- Alterations in functional connectivity and interactions in resting-state networks in female patients with functional constipation.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Functional Neuroimaging in Irritable Bowel Syndrome: A Systematic Review Highlights Common Brain Alterations With Functional Movement Disorders.Journal of neurogastroenterology and motility · 2022Review
- A neuropsychosocial signature predicts longitudinal symptom changes in women with irritable bowel syndrome.Molecular psychiatry · 2022Article
- Resting state functional connectivity of the pain matrix and default mode network in irritable bowel syndrome: a graph theoretical analysis.Scientific reports · 2020Article
- Review
- Defense Mechanisms in Patients with Irritable Bowel Syndrome and Their Relationship with Symptom Severity and Quality of Life.Middle East journal of digestive diseases · 2019Article
- Article
- Nesfatin-1 in the dorsal raphe nucleus influences visceral sensitivity via 5-HT neurons in male maternally separated rats.Scientific reports · 2018Article
- White Matter Microstructural Similarity and Diversity of Functional Constipation and Constipation-predominant Irritable Bowel Syndrome.Journal of neurogastroenterology and motility · 2018Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundEarly adverse life events (EALs) and sex have been identified as vulnerability factors for the development of several stress-sensitive disorders, including irritable bowel syndrome (IBS). We aimed to identify disease and sex-based differences in resting state (RS) connectivity associated with EALs in individuals with IBS.
methodA history of EALs before age 18 years was assessed using the early trauma inventory. RS functional magnetic resonance imaging was used to identify patterns of intrinsic brain oscillations in the form of RS networks in 168 people (58 people with IBS, 28 were female; 110 healthy controls, 72 were female). Partial least squares, a multivariate analysis technique, was used to identify disease and sex differences and possible correlations between EALs and functional connectivity in six identified RS networks.
resultsAssociations between EALs and RS networks were observed. Although a history of EALs was associated with altered connectivity in the salience/executive control network to a similar extent in male and female patients with IBS (bootstrap ratio = 3.28-5.61; p = .046), male patients with IBS demonstrated additional EAL-related alterations in the cerebellar network (bootstrap ratio = 3.92-6.79; p = .022).
conclusionsThis cross sectional study identified correlations between RS networks and EALs in individuals with IBS. These results suggest that exposure to EALs before age 18 years can shape adult RS in both male and female patients in the salience/executive control network, a brain network that has been implicated in the pathophysiology of central pain amplification.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.