ArticlePloS one2014
miR-485-5p binding site SNP rs8752 in HPGD gene is associated with breast cancer risk.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- Article
- Review
- FCGCNMDA: predicting miRNA-disease associations by applying fully connected graph convolutional networks.Molecular genetics and genomics : MGG · 2020Article
- The emerging roles of non-coding competing endogenous RNA in hepatocellular carcinoma.Cancer cell international · 2020Review
- CLDN10 single nucleotide polymorphism rs1325774 alters the risk of breast cancer in south chinese women.Medicine · 2018Article
- Deciphering splenic marginal zone lymphoma pathogenesis: the proposed role of microRNA.Oncotarget · 2018Review
- A tumor-suppressive microRNA, miRNA-485-5p, inhibits glioma cell proliferation and invasion by down-regulating TPD52L2.American journal of translational research · 2017Article
- MicroRNAs and Their Impact on Breast Cancer, the Tumor Microenvironment, and Disparities.Advances in cancer research · 2017Review
- A Single Nucleotide Polymorphism inJournal of Cancer · 2017Article
- UCA1 functions as a competing endogenous RNA to suppress epithelial ovarian cancer metastasis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- A functional single nucleotide polymorphism of SET8 is prognostic for breast cancer.Oncotarget · 2016Article
- MiR-485-3p and miR-485-5p suppress breast cancer cell metastasis by inhibiting PGC-1α expression.Cell death & disease · 2016Article
- MicroRNA expression profiles differentiate chronic pain condition subtypes.Translational research : the journal of laboratory and clinical medicine · 2015Article
- Evaluation of miRNA-binding-site SNPs of MRE11A, NBS1, RAD51 and RAD52 involved in HRR pathway genes and risk of breast cancer in China.Molecular genetics and genomics : MGG · 2015Article
- miR-485-5p acts as a negative regulator in gastric cancer progression by targeting flotillin-1.American journal of translational research · 2015Article
- Critical analysis of the potential for microRNA biomarkers in breast cancer management.Breast cancer (Dove Medical Press) · 2015Review
- MicroRNA-485-5p suppresses cell proliferation and invasion in hepatocellular carcinoma by targeting stanniocalcin 2.International journal of clinical and experimental pathology · 2015Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSingle nucleotide polymorphisms (SNPs) that reside in microRNA target sites may play an important role in breast cancer development and progression. To reveal the association between microRNA target site SNPs and breast cancer risk, we performed a large case-control study in China.
methodsWe performed a two-stage case-control study including 2744 breast cancer cases and 3125 controls. In Stage I, we genotyped 192 SNPs within microRNA binding sites identified from the "Patrocles" database using custom Illumina GoldenGate VeraCode assays on the Illumina BeadXpress platform. In Stage II, genotyping was performed on SNPs potentially associated with breast cancer risk using the TaqMan platform in an independent replication set.
resultsIn stage I, 15 SNPs were identified to be significantly associated with breast cancer risk (P<0.05). In stage II, one SNP rs8752 was replicated at P<0.05. This SNP is located in the 3' untranslated region (UTR) of the 15-hydroxyprostaglandin dehydrogenase (HPGD) gene at 4q34-35, a miR-485-5p binding site. Compared with the GG genotype, the combined GA+AA genotypes has a significantly higher risk of breast cancer (OR = 1.18; 95% CI: 1.06-1.31, P = 0.002). Specifically, this SNP was associated with estrogen receptor (ER) positive breast cancer (P = 0.0007), but not with ER negative breast cancer (P = 0.23), though p for heterogeneity not significant.
conclusionThrough a systematic case-control study of microRNA binding site SNPs, we identified a new breast cancer risk variant rs8752 in HPGD in Chinese women. Further studies are warranted to investigate the underling mechanism for this association.
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