Evidence map›Paper›PMID 25003825›Full record

ReviewRNA biology2013

RNA-directed DNA methylation in plants: Where to start?

Heng Zhang, Xinjian He, Jian-Kang Zhu

Abstract readReview
In one paragraph

Review in RNA biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. RNA-directed DNA methylation in plants.Plant cell reports · 2015
    Article
  14. Exploring the secrets of long noncoding RNAs.International journal of molecular sciences · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Heng ZhangShanghai Center for Plant Stress Biology; Shanghai Institute of Biological Sciences; Chinese Academy of Sciences; Shanghai, P.R. China.
Xinjian HeNational Institute of Biological Sciences; Beijing, P.R. China.
Jian-Kang ZhuShanghai Center for Plant Stress Biology; Shanghai Institute of Biological Sciences; Chinese Academy of Sciences; Shanghai, P.R. China; Department of Horticulture and Landscape Architecture; Purdue University; West Lafayette, IN USA.

Funding

CALCIUM SIGNALING--INTRACELL ION HOMEOSTASIS REGULATIONR01GM059138 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI ZHU, JIAN-KANG · 1999 to 2015
$4.4M
DNA Demethylation and Transcriptional Gene SilencingR01GM070795 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI ZHU, JIAN-KANG · 2004 to 2015
$4.0M
NIGMS NIH HHS R01GM059138NIGMS NIH HHS R01 GM070795NIGMS NIH HHS R01GM070795
6 · The paper itself

Abstract

Plants use 24-nucleotide small interfering RNAs (24-nt siRNAs) and long non-coding RNAs (lncRNAs) to direct de novo DNA methylation and transcriptional gene silencing. This process is called RNA-directed DNA methylation (RdDM). An important question in the RdDM model is what explains the target specificity of RNA polymerase IV (Pol IV), the enzyme that initiates siRNA production. Two recent papers addressed this question by characterizing the DTF1/SHH1 protein, which contains a homeodomain in the N-terminus and a novel histone-binding domain SAWADEE in the C terminus. Here we review the main results of the two studies and discuss several possible mechanisms that could contribute to Pol IV and Pol V recruitment.

Indexed as

DNA MethylationGene Expression Regulation, PlantArabidopsisArabidopsis ProteinsDNA-Directed RNA PolymerasesRNA, PlantRNA, Small InterferingArabidopsis ProteinsDNA-Directed RNA PolymerasesRNA, PlantRNA polymerase IV, ArabidopsisRNA polymerase V, ArabidopsisRNA, Small InterferingDNA methylationhistone modificationlncRNARdDMsiRNA

Identifiers

PMID25003825
PMCPMC3866238

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.