ArticlePloS one2014
Pathological features and survival outcomes of young patients with operable colon cancer: are they homogeneous?
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Early-Onset Colorectal Cancer in Egypt: Pathological Characters, Patterns of Care, and Survival Compared to Average-Age Onset Colorectal Cancer: A Retrospective Multicenter Study.JCO global oncology · 2024Article
- Mismatch Repair Status Correlates with Survival in Young Adults with Metastatic Colorectal Cancer.The Journal of surgical research · 2021Article
- Molecular Analyses of Left- and Right-Sided Tumors in Adolescents and Young Adults with Colorectal Cancer.The oncologist · 2020Article
- Clinicopathologic and Racial/Ethnic Differences of Colorectal Cancer Among Adolescents and Young Adults.Clinical and translational gastroenterology · 2019Article
- Impact of Patient Age on Molecular Alterations of Left-Sided Colorectal Tumors.The oncologist · 2019Article
- Age-specific impact on the survival of gastric cancer patients with distant metastasis: an analysis of SEER database.Oncotarget · 2017Article
- Poor prognosis of young patients with colorectal cancer: a retrospective study.International journal of colorectal disease · 2017Article
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Authors and funding
6 authors.
Funding
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Abstract
objectiveTo compare the pathological features and survival outcomes at different age subgroups of young patients with colon cancer.
methodsUsing Surveillance, Epidemiology, and End Results (SEER) population-based data, we identified 2,861 young patients with colon cancer diagnosed between 1988 and 2005 treated with surgery. Patients were divided into four groups: group 1 (below 25 years), group 2 (26-30 years), group 3 (31-35 years) and group 4 (36-40 years). Five-year cancer specific survival data were obtained. Kaplan-Meier methods were adopted and multivariable Cox regression models were built for the analysis of long-term survival outcomes and risk factors.
resultsThere were significant different among four groups in pathological grading, histological type, AJCC stage, current standard (≥12 lymph nodes retrieval), mean number of lymph nodes examined and positive lymph nodes (p<0.001). The 5-year cause specific survival was 71.0% in group 1, 75.1% in group 2, 80.6% in group 3 and 82.5% in group 4, which had significant difference in both univariate (P = 0.002) and multivariate analysis (P = 0.041).
conclusionsYoung patients with colon cancer at age 18-40 years are essentially a heterogeneous group. Patients at age 31-35, 36-40 subgroups have more favorable clinicopathologic characteristics and better cancer specific survival than below 30 years.
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