ArticleAIDS (London, England)2014
Markers of inflammation and activation of coagulation are associated with anaemia in antiretroviral-treated HIV disease.
Article in AIDS (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Anaemia is associated with monocyte activation in HIV-infected adults on antiretroviral therapy.Antiviral therapy · 2015Trial
- Impact of a factor Xa inhibitor (apixaban) on SIV pathogenesis and response to antiretroviral therapy.JCI insight · 2026Article
- Evaluation of mean corpuscular volume among anemic people with HIV in North America following ART initiation.AIDS research and therapy · 2024Article
- A Perfect Storm: The Convergence of Aging, Human Immunodeficiency Virus Infection, and Inflammasome Dysregulation.Current issues in molecular biology · 2024Review
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- Multiplex Analysis of Cytokines and Chemokines in Persons Aging With or Without HIV.AIDS research and human retroviruses · 2023Article
- Effect of the relationship between anaemia and systemic inflammation on the risk of incident tuberculosis and death in people with advanced HIV: a sub-analysis of the REMEMBER trial.EClinicalMedicine · 2023Article
- Sex Differences in the Treatment of HIV.Current HIV/AIDS reports · 2020Review
- High levels of serum IL-6 and serum hepcidin and low CD4 cell count were risk factors of anemia of chronic disease in HIV patients on the combination of antiretroviral therapy.HIV/AIDS (Auckland, N.Z.) · 2019Article
- Longitudinal evaluation of markers of inflammation in HIV-positive and HIV-negative Rwandan women.HIV medicine · 2018Observational
- In silico thrombin generation: Plasma composition imbalance and mortality in human immunodeficiency virus.Research and practice in thrombosis and haemostasis · 2018Article
- Cardiovascular Risk Profile of Transgender Women With HIV: A US Health Care Database Study.Journal of acquired immune deficiency syndromes (1999) · 2018Article
- The impact of antiretroviral therapy on iron homeostasis and inflammation markers in HIV-infected patients with mild anemia.Journal of translational medicine · 2017Article
- Interleukin 6 Is a Stronger Predictor of Clinical Events Than High-Sensitivity C-Reactive Protein or D-Dimer During HIV Infection.The Journal of infectious diseases · 2016Article
- Anemia and Red Blood Cell Indices Predict HIV-Associated Neurocognitive Impairment in the Highly Active Antiretroviral Therapy Era.The Journal of infectious diseases · 2016Article
- Factors Associated With Plasma IL-6 Levels During HIV Infection.The Journal of infectious diseases · 2015Article
- Why START? Reflections that led to the conduct of this large long-term strategic HIV trial.HIV medicine · 2015Article
- Lower coronary plaque burden in patients with HIV presenting with acute coronary syndrome.Open heartArticle
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 6 countries.
Funding
Abstract
objectiveThe objective of this study is to determine the relationship between inflammatory interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hsCRP)] and coagulation (D-dimer) biomarkers and the presence and type of anaemia among HIV-positive individuals.
designA cross-sectional study.
methodsCombination antiretroviral therapy (cART)-treated adults participating in an international HIV trial with haemoglobin and mean corpuscular volume (MCV) measurements at entry were categorized by presence of anaemia (haemoglobin ≤14 g/dl in men and ≤12 g/dl in women) and, for those with anaemia, by type [microcytic (MCV < 80 fl), normocytic (80-100 fl), macrocytic (>100 fl)]. We analysed the association between inflammation (IL-6 and hsCRP) and coagulation (D-dimer) and haemoglobin, controlling for demographics (age, race and sex), BMI, HIV plasma RNA levels, CD4⁺ T-cell counts (nadir and baseline), Karnofsky score, previous AIDS diagnosis, hepatitis B/C coinfection and use of zidovudine.
resultsAmong 1410 participants, 313 (22.2%) had anaemia. Of these, 4.1, 27.2 and 68.7% had microcytic, normocytic and macrocytic anaemia, respectively. When compared with participants with normal haemoglobin values, those with anaemia were more likely to be older, black, male and on zidovudine. They also had lower baseline CD4⁺ T-cell counts and lower Karnofsky scores. Adjusted relative odds of anaemia per two-fold higher biomarker levels were 1.22 (P = 0.007) for IL-6, 0.99 for hsCRP (P = 0.86) and 1.35 (P < 0.001) for D-dimer. Similar associations were seen in those with normal and high MCV values.
conclusionPersistent inflammation and hypercoagulation appear to be associated with anaemia. Routine measurements of haemoglobin might provide insights into the inflammatory state of treated HIV infection.
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