Evidence map›Paper›PMID 25003603›Full record

ReviewCurrent opinion in gastroenterology2014

Recent advances in the regulation of pancreatic secretion.

Rashmi Chandra, Rodger A Liddle

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. GDF15: a potential therapeutic target for type 1 diabetes.Expert opinion on therapeutic targets · 2022
    Review
  5. Review
  6. Pancreas-Brain Crosstalk.Frontiers in neuroanatomy · 2021
    Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Rashmi ChandraaDepartment of Medicine, Division of Gastroenterology, Duke University bVA Medical Center, Durham, North Carolina, USA.
Rodger A Liddle
Duke University · USDurham VA Medical Center · US

Funding

Pathogenic Mechanisms of PancreatitisR01DK064213 · NIDDK · DUKE UNIVERSITY · PI LIDDLE, RODGER A. · 2004 to 2017
$4.7M
Mechanisms Regulating Gastrointestinal Hormone SecretionR01DK091946 · NIDDK · DUKE UNIVERSITY · PI LIDDLE, RODGER A. · 2011 to 2015
$1.7M
Receptor Regulation of CCK Cell FunctionR01DK098796 · NIDDK · DUKE UNIVERSITY · PI LIDDLE, RODGER A. · 2013 to 2016
$1.4M
NIDDK NIH HHS DK-064213NIDDK NIH HHS DK-091946NIDDK NIH HHS DK-098796NIDDK NIH HHS R01 DK064213NIDDK NIH HHS R01 DK091946NIDDK NIH HHS R01 DK098796
6 · The paper itself

Abstract

purpose of reviewThis review highlights recent progress made in the field of pancreatic secretion. RECENT

findingsThis review summarizes a number of recent studies demonstrating the intracellular pathways by which hormones and neural inputs regulate pancreatic exocrine and endocrine secretion. In particular, the effects of vasoactive intestinal peptide and secretin on intra-acinar cell adenosine 3',5'-cyclic monophosphate are explored. Considerable attention is paid to regulation of β-cell function and includes studies detailing the mechanisms of regulation of insulin by somatostatin, serotonin, and melanocortins. These studies emphasize the critical role that hormonal, paracrine, and neural factors play in glucose homeostasis. SUMMARY: Exocrine and endocrine pancreatic secretions are regulated by hormonal and neural mechanisms, and understanding these pathways will enable the discovery and design of new and improved therapies for prevention and control of diabetes and perhaps exocrine insufficiency.

Indexed as

Blood GlucoseDiabetes MellitusHormonesHumansInsulinInsulin SecretionPancreas, ExocrineBlood GlucoseHormonesInsulin

Identifiers

PMID25003603
PMCPMC4229368
OpenAlexW2061292622

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.